About: Rad52 SUMOylation affects the efficiency of the DNA repair

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Homologous recombination (HR) plays a vital role in DNA metabolic processes including meiosis, DNA repair, DNA replication, and rDNA homeostasis. HR defects can lead to pathological outcomes, including genetic diseases and cancer. Recent studies suggest that the post-translational modification by the small ubiquitin-like modifier (SUMO) protein plays an important role in mitotic and meiotic recombination. However, the precise role of SUMOylation during recombination is still unclear. Here, we characterize the effect of SUMOylation on the biochemical properties of the Saccharomyces cerevisiae recombination mediator protein Rad52. Interestingly, Rad52 SUMOylation is enhanced by ssDNA, and we show that SUMOylation of Rad52 also inhibits its DNA binding and annealing activities. Homologous recombination (HR) plays a vital role in DNA metabolic processes including meiosis, DNA repair, DNA replication, and rDNA homeostasis. HR defects can lead to pathological outcomes, including genetic diseases and cancer. Recent studies suggest that the post-translational modification by the small ubiquitin-like modifier (SUMO) protein plays an important role in mitotic and meiotic recombination. However, the precise role of SUMOylation during recombination is still unclear. Here, we characterize the effect of SUMOylation on the biochemical properties of the Saccharomyces cerevisiae recombination mediator protein Rad52. Interestingly, Rad52 SUMOylation is enhanced by ssDNA, and we show that SUMOylation of Rad52 also inhibits its DNA binding and annealing activities. (en)
Title	Rad52 SUMOylation affects the efficiency of the DNA repair Rad52 SUMOylation affects the efficiency of the DNA repair (en)
skos:prefLabel	Rad52 SUMOylation affects the efficiency of the DNA repair Rad52 SUMOylation affects the efficiency of the DNA repair (en)
skos:notation	RIV/00216224:14310/10:00043447!RIV11-GA0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/09/1917), P(GD203/09/H046), P(LC06030), P(ME10048), Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Damborský, Jiří Chaloupková, Radka Krejčí, Lumír Altmannová, Veronika Kolesár, Peter
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	283805
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00043447
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA repair; DNA damage; replication; genomic instability (en)
http://linked.open.../riv/klicoveSlovo	replication DNA damage DNA repair genomic instability
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B9EF43AA4496]
http://linked.open...i/riv/nazevZdroje	Nucleic Acids Research
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomolecular centre Biochemistry on the crossroad from in silico to in vitro Resolution of replication-recombination DNA intermediates and its role in genomic instability The role of post-translational modification in DNA repair and recombination: Meiosis, SUMOylation and Zip3 protein
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	38
http://linked.open...iv/tvurceVysledku	Chaloupková, Radka Damborský, Jiří Krejčí, Lumír Altmannová, Veronika Kolesár, Peter Zhao, Xiaolan Lisby, Michael Arneric, Milica Eckert-Boulet, Nadine Sung, Patrick
http://linked.open...ain/vavai/riv/wos	000280922400022
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
issn	0305-1048
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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