About: Expression of hippocampal NMDA receptor GluN1 subunit and its splicing isoforms in schizophrenia: postmortem study

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About: Expression of hippocampal NMDA receptor GluN1 subunit and its splicing isoforms in schizophrenia: postmortem study Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	There is accumulating evidence that disturbances in the N-methyl-D-aspartate receptor (NMDA-R) functioning are associated with the pathogenesis of schizophrenia. To assess actual changes in the expression of the GluN1 subunit and its isoforms, we measured absolute differences in the levels of mRNA/protein for panGluN1 (8 isoforms altogether) as well as the mRNA individual isoforms in the post-mortem left/right hippocampus of patients with schizophrenia in comparison with non-psychiatric subjects. There were no significant differences in the panGluN1subunit mRNA expression, but the absolute left-right differences were much more pronounced in the patients with schizophrenia. Protein levels of the GluN1 subunit in the left hippocampus in male schizophrenic patients were lower in comparison with controls. The expression of the NR1-4b isoform was attenuated in the left whereas the NR1-2b was reduced in the right hippocampus of schizophrenic patients. There is accumulating evidence that disturbances in the N-methyl-D-aspartate receptor (NMDA-R) functioning are associated with the pathogenesis of schizophrenia. To assess actual changes in the expression of the GluN1 subunit and its isoforms, we measured absolute differences in the levels of mRNA/protein for panGluN1 (8 isoforms altogether) as well as the mRNA individual isoforms in the post-mortem left/right hippocampus of patients with schizophrenia in comparison with non-psychiatric subjects. There were no significant differences in the panGluN1subunit mRNA expression, but the absolute left-right differences were much more pronounced in the patients with schizophrenia. Protein levels of the GluN1 subunit in the left hippocampus in male schizophrenic patients were lower in comparison with controls. The expression of the NR1-4b isoform was attenuated in the left whereas the NR1-2b was reduced in the right hippocampus of schizophrenic patients. (en)
Title	Expression of hippocampal NMDA receptor GluN1 subunit and its splicing isoforms in schizophrenia: postmortem study Expression of hippocampal NMDA receptor GluN1 subunit and its splicing isoforms in schizophrenia: postmortem study (en)
skos:prefLabel	Expression of hippocampal NMDA receptor GluN1 subunit and its splicing isoforms in schizophrenia: postmortem study Expression of hippocampal NMDA receptor GluN1 subunit and its splicing isoforms in schizophrenia: postmortem study (en)
skos:notation	RIV/00216224:14310/10:00040731!RIV11-MZ0-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR9324)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Šerý, Omar Lochman, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	258521
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00040731
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Schizophrenia; Hippocampus; GluN1 subunit of NMDA receptor; splice variants; laterality (en)
http://linked.open.../riv/klicoveSlovo	Schizophrenia Hippocampus laterality GluN1 subunit of NMDA receptor splice variants
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C0CE35ED5EED]
http://linked.open...i/riv/nazevZdroje	Neurochemical Research
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	The candidate genes for schizophrenia: the influence on phenotypic variability in patients and in vitro manipulation of gene expression by the use of siRNA.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	2010
http://linked.open...iv/tvurceVysledku	Horáček, Jiří Höschl, Cyril Peková, Soňa Šerý, Omar Šťastný, František Vrajová, Monika Lochman, Jan Klaschka, Jan
issn	0364-3190
number of pages	15 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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