About: c-Myb-induced migration and invasiveness of breast and colon cancer cells are associated with up-regulation of cathepsin D

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About: c-Myb-induced migration and invasiveness of breast and colon cancer cells are associated with up-regulation of cathepsin D Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	c-Myb is essential regulator of stem-progenitor cells in bone marrow, colon epithelia and neurogenic niches in brain. Malfunction of c-Myb results in malignancies of several types including breast and colon cancer. Its role in control of invasion and metastasis of tumor cells remains unclear. This study shows that overexpession of c-Myb enhances ability of human breast cancer MDA-MB-231 cells and mouse colon cancer CT26 cells to migrate and invade Matrigel in vitro. Real-time analysis of cell migration and invasion using the xCELLigence RTCA system revealed dynamics of c-Myb-induced effects with rapid onset of migration and invasion during first 6 and 12 hours, respectively. Real-time PCR screening revealed up-regulation of cathepsin D and matrix metalloproteinase 9 (MMP9) mRNAs coding for proteases that promote invasive behavior in c-Myb-overexpressing cells. Further experiments confirmed that increased production of cathepsin D and MMP 9 correlate with c-Myb-induced invasivity of MDA-MB-231 cells. c-Myb is essential regulator of stem-progenitor cells in bone marrow, colon epithelia and neurogenic niches in brain. Malfunction of c-Myb results in malignancies of several types including breast and colon cancer. Its role in control of invasion and metastasis of tumor cells remains unclear. This study shows that overexpession of c-Myb enhances ability of human breast cancer MDA-MB-231 cells and mouse colon cancer CT26 cells to migrate and invade Matrigel in vitro. Real-time analysis of cell migration and invasion using the xCELLigence RTCA system revealed dynamics of c-Myb-induced effects with rapid onset of migration and invasion during first 6 and 12 hours, respectively. Real-time PCR screening revealed up-regulation of cathepsin D and matrix metalloproteinase 9 (MMP9) mRNAs coding for proteases that promote invasive behavior in c-Myb-overexpressing cells. Further experiments confirmed that increased production of cathepsin D and MMP 9 correlate with c-Myb-induced invasivity of MDA-MB-231 cells. (en)
Title	c-Myb-induced migration and invasiveness of breast and colon cancer cells are associated with up-regulation of cathepsin D c-Myb-induced migration and invasiveness of breast and colon cancer cells are associated with up-regulation of cathepsin D (en)
skos:prefLabel	c-Myb-induced migration and invasiveness of breast and colon cancer cells are associated with up-regulation of cathepsin D c-Myb-induced migration and invasiveness of breast and colon cancer cells are associated with up-regulation of cathepsin D (en)
skos:notation	RIV/00216224:14310/10:00040620!RIV11-GA0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/09/1115), P(GD204/08/H054), P(IAA501630801), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Beneš, Petr Šmarda, Jan Pekarčíková, Lucie Knopfová, Lucia
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	251019
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00040620
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	c-Myb; migration; breast carcinoma; colon carcinoma (en)
http://linked.open.../riv/klicoveSlovo	c-Myb migration breast carcinoma colon carcinoma
http://linked.open...ontrolniKodProRIV	[7D03D170F9C6]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of c-Myb and Cox-2 proteins in colon carcinogenesis Molecular mechanisms of the cell proliferation and differentiation Mechanism of procathepsin D effect on breast cancer cells
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Beneš, Petr Knopfová, Lucia Pekarčíková, Lucie Šmarda, Jan
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
http://localhost/t...ganizacniJednotka	14310

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