About: The c-Myb protein promotes motility and invasion of breast cancer cells

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The c-Myb protein promotes motility and invasion of breast cancer cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	c-Myb is a key regulator of progenitor cells in bone marrow, colonic crypts and adult brain. Activation of c-myb is associated with leukemias and solid tumors. The aim of this study was to assess the role of the c-Myb protein in control of invasion of breast cancer cells. c-Myb overexpression enhanced migration and invasiveness of MDA-MB-231 cells as determined by transwell cell invasion assay and real-time analysis of cell migration and invasion using the xCELLigence RTCA system. qRT-PCR analysis revealed c-Myb-dependent upregulation of the genes coding for proteases that are involved in invasive behavior of MDA-MB-231 cells: increased production of cathepsin D and matrix metalloproteinase 9 (MMP9) in MDA-MB-231MYBup cells were further confirmed by western blotting. Transactivation assay revealed that c-Myb can activate transcription from the cathepsin D promoter. This denotes cathepsin D as a novel Myb-target gene. c-Myb promotes motility and invasivity of breast cancer MDA-MB-231 cells. c-Myb is a key regulator of progenitor cells in bone marrow, colonic crypts and adult brain. Activation of c-myb is associated with leukemias and solid tumors. The aim of this study was to assess the role of the c-Myb protein in control of invasion of breast cancer cells. c-Myb overexpression enhanced migration and invasiveness of MDA-MB-231 cells as determined by transwell cell invasion assay and real-time analysis of cell migration and invasion using the xCELLigence RTCA system. qRT-PCR analysis revealed c-Myb-dependent upregulation of the genes coding for proteases that are involved in invasive behavior of MDA-MB-231 cells: increased production of cathepsin D and matrix metalloproteinase 9 (MMP9) in MDA-MB-231MYBup cells were further confirmed by western blotting. Transactivation assay revealed that c-Myb can activate transcription from the cathepsin D promoter. This denotes cathepsin D as a novel Myb-target gene. c-Myb promotes motility and invasivity of breast cancer MDA-MB-231 cells. (en)
Title	The c-Myb protein promotes motility and invasion of breast cancer cells The c-Myb protein promotes motility and invasion of breast cancer cells (en)
skos:prefLabel	The c-Myb protein promotes motility and invasion of breast cancer cells The c-Myb protein promotes motility and invasion of breast cancer cells (en)
skos:notation	RIV/00216224:14310/10:00040584!RIV11-GA0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/09/1115), P(GD204/08/H054), P(IAA501630801), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Beneš, Petr Šmarda, Jan Knopfová, Lucia
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	251018
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00040584
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	c-Myb; invasion; migration; breast carcinoma (en)
http://linked.open.../riv/klicoveSlovo	c-Myb migration invasion breast carcinoma
http://linked.open...ontrolniKodProRIV	[BFC8770B5DB0]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of c-Myb and Cox-2 proteins in colon carcinogenesis Molecular mechanisms of the cell proliferation and differentiation Mechanism of procathepsin D effect on breast cancer cells
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Beneš, Petr Knopfová, Lucia Pekarčíková, Lucie Šmarda, Jan Trčka, Filip
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
http://localhost/t...ganizacniJednotka	14310

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software