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rdf:type
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Description
| - c-Myb is a key regulator of progenitor cells in bone marrow, colonic crypts and adult brain. Activation of c-myb is associated with leukemias and solid tumors. The aim of this study was to assess the role of the c-Myb protein in control of invasion of breast cancer cells. c-Myb overexpression enhanced migration and invasiveness of MDA-MB-231 cells as determined by transwell cell invasion assay and real-time analysis of cell migration and invasion using the xCELLigence RTCA system. qRT-PCR analysis revealed c-Myb-dependent upregulation of the genes coding for proteases that are involved in invasive behavior of MDA-MB-231 cells: increased production of cathepsin D and matrix metalloproteinase 9 (MMP9) in MDA-MB-231MYBup cells were further confirmed by western blotting. Transactivation assay revealed that c-Myb can activate transcription from the cathepsin D promoter. This denotes cathepsin D as a novel Myb-target gene. c-Myb promotes motility and invasivity of breast cancer MDA-MB-231 cells.
- c-Myb is a key regulator of progenitor cells in bone marrow, colonic crypts and adult brain. Activation of c-myb is associated with leukemias and solid tumors. The aim of this study was to assess the role of the c-Myb protein in control of invasion of breast cancer cells. c-Myb overexpression enhanced migration and invasiveness of MDA-MB-231 cells as determined by transwell cell invasion assay and real-time analysis of cell migration and invasion using the xCELLigence RTCA system. qRT-PCR analysis revealed c-Myb-dependent upregulation of the genes coding for proteases that are involved in invasive behavior of MDA-MB-231 cells: increased production of cathepsin D and matrix metalloproteinase 9 (MMP9) in MDA-MB-231MYBup cells were further confirmed by western blotting. Transactivation assay revealed that c-Myb can activate transcription from the cathepsin D promoter. This denotes cathepsin D as a novel Myb-target gene. c-Myb promotes motility and invasivity of breast cancer MDA-MB-231 cells. (en)
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Title
| - The c-Myb protein promotes motility and invasion of breast cancer cells
- The c-Myb protein promotes motility and invasion of breast cancer cells (en)
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skos:prefLabel
| - The c-Myb protein promotes motility and invasion of breast cancer cells
- The c-Myb protein promotes motility and invasion of breast cancer cells (en)
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skos:notation
| - RIV/00216224:14310/10:00040584!RIV11-GA0-14310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA301/09/1115), P(GD204/08/H054), P(IAA501630801), Z(MSM0021622415)
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/10:00040584
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - c-Myb; invasion; migration; breast carcinoma (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Beneš, Petr
- Knopfová, Lucia
- Pekarčíková, Lucie
- Šmarda, Jan
- Trčka, Filip
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http://linked.open...n/vavai/riv/zamer
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http://localhost/t...ganizacniJednotka
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