About: Wedelolactone suppresses growth and induces differentiation and apoptosis of breast cancer cells

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About: Wedelolactone suppresses growth and induces differentiation and apoptosis of breast cancer cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Wedelolactone is an active polyphenolic coumestan isolated from the plant extracts of Wedelia chinensis and Eclipta prostrata. Recently, wedelolactone has been shown to reduce growth cancer cells. These effects were attributed to the inhibition of NFkB and androgen receptors. In this study, we tested the effect of wedelolactone on proliferation, differentiation and apoptosis of breast cancer MDA-MB-231 cells. Wedelolactone in uM concentrations suppresses growth of MDA-MB-231 cells by blocking cell cycle progression in the S- and G2/M phases. The 10 uM wedelolactone induces cell differentiation and the 30 uM wedelolactone reduces viability and induces apoptosis of MDA-MB-231 cells. We found that the growth inhibitory and proapoptotic effects of wedelolactone do not result from deregulation of NFkB activity but they are more likely to be attributed to its ability to bind dsDNA, to inhibit topoisomerase IIa and to induce DNA damage. Wedelolactone is an active polyphenolic coumestan isolated from the plant extracts of Wedelia chinensis and Eclipta prostrata. Recently, wedelolactone has been shown to reduce growth cancer cells. These effects were attributed to the inhibition of NFkB and androgen receptors. In this study, we tested the effect of wedelolactone on proliferation, differentiation and apoptosis of breast cancer MDA-MB-231 cells. Wedelolactone in uM concentrations suppresses growth of MDA-MB-231 cells by blocking cell cycle progression in the S- and G2/M phases. The 10 uM wedelolactone induces cell differentiation and the 30 uM wedelolactone reduces viability and induces apoptosis of MDA-MB-231 cells. We found that the growth inhibitory and proapoptotic effects of wedelolactone do not result from deregulation of NFkB activity but they are more likely to be attributed to its ability to bind dsDNA, to inhibit topoisomerase IIa and to induce DNA damage. (en)
Title	Wedelolactone suppresses growth and induces differentiation and apoptosis of breast cancer cells Wedelolactone suppresses growth and induces differentiation and apoptosis of breast cancer cells (en)
skos:prefLabel	Wedelolactone suppresses growth and induces differentiation and apoptosis of breast cancer cells Wedelolactone suppresses growth and induces differentiation and apoptosis of breast cancer cells (en)
skos:notation	RIV/00216224:14310/10:00040583!RIV11-GA0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GD204/08/H054), P(IAA501630801), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Beneš, Petr Šmarda, Jan Knopfová, Lucia Trčka, Filip
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	298707
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/10:00040583
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	wedelolactone; breast cancer; growth; differentiation; apoptosis (en)
http://linked.open.../riv/klicoveSlovo	breast cancer growth apoptosis wedelolactone differentiation
http://linked.open...ontrolniKodProRIV	[5B476BD59C72]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanisms of the cell proliferation and differentiation Mechanism of procathepsin D effect on breast cancer cells
http://linked.open...UplatneniVysledku	2010
http://linked.open...iv/tvurceVysledku	Beneš, Petr Knopfová, Lucia Šmarda, Jan Nemajerová, Alice Pinheiro, Diana Trčka, Filip
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
http://localhost/t...ganizacniJednotka	14310

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