About: Metal complexes of macrocyclic ligands mimicking enzyme activity

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Metal ions form with macrocyclic ligands more stable complexes than with analogous acyclic ligands from both thermodynamic and kinetic point of view. These complexes can be studied as suitable models in order to mimic the metaloenzyme activity. In this contribution, the catalytic activity of [M(cyclen)]2+ complexes (M = Zn, Cd, Cu, Ni, cyclen = 1,4,7,10-tetraazacyclodecane, [12]aneN4) which are mimicking enzymes was investigated for hydrolysis of acetic acid esters acting as substrate. The rate of ester hydrolysis was monitored by molecular absorption (for 4-nitrophenylacetate) or luminescence (for 4-methylumbelliferylacetate) spectroscopy and optimal experimental conditions (e.g. temperature, pH, buffer, etc.) were found. The catalytic activity of the most active Zn(II) and Cd(II) metal complexes is inhibited by some compounds due to formation of stable ternary complexes. The influence of various inhibiting agents (mostly base, e.g. Metal ions form with macrocyclic ligands more stable complexes than with analogous acyclic ligands from both thermodynamic and kinetic point of view. These complexes can be studied as suitable models in order to mimic the metaloenzyme activity. In this contribution, the catalytic activity of [M(cyclen)]2+ complexes (M = Zn, Cd, Cu, Ni, cyclen = 1,4,7,10-tetraazacyclodecane, [12]aneN4) which are mimicking enzymes was investigated for hydrolysis of acetic acid esters acting as substrate. The rate of ester hydrolysis was monitored by molecular absorption (for 4-nitrophenylacetate) or luminescence (for 4-methylumbelliferylacetate) spectroscopy and optimal experimental conditions (e.g. temperature, pH, buffer, etc.) were found. The catalytic activity of the most active Zn(II) and Cd(II) metal complexes is inhibited by some compounds due to formation of stable ternary complexes. The influence of various inhibiting agents (mostly base, e.g. (en)
Title	Metal complexes of macrocyclic ligands mimicking enzyme activity Metal complexes of macrocyclic ligands mimicking enzyme activity (en)
skos:prefLabel	Metal complexes of macrocyclic ligands mimicking enzyme activity Metal complexes of macrocyclic ligands mimicking enzyme activity (en)
skos:notation	RIV/00216224:14310/09:00037452!RIV11-MSM-14310___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(LC06035), P(ME09065), S
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Štěpánek, Antonín Lubal, Přemysl Jarolímová, Zdeňka
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	325602
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/09:00037452
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	macrocyclic ligands; metal complexes; enzyme; analytical determination; nucleotides (en)
http://linked.open.../riv/klicoveSlovo	analytical determination metal complexes enzyme macrocyclic ligands nucleotides
http://linked.open...ontrolniKodProRIV	[305624E8F48C]
http://linked.open...v/mistoKonaniAkce	Debrecen
http://linked.open...i/riv/mistoVydani	Debrecen
http://linked.open...i/riv/nazevZdroje	Abstract Book of ISABC 10 conference (International Symposium on Applied Bioinorganic Chemistry)
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine. Research of new detection systems based on sensor arrays for application in speciation analysis
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Jarolímová, Zdeňka Lubal, Přemysl Štěpánek, Antonín
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2009-01-01 (xsd:date)
number of pages	224 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Department of Inorganic and Analytical Chemistry, Debrecen University
https://schema.org/isbn	978-963-473-307-2
http://localhost/t...ganizacniJednotka	14310

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