About: Specificity and affinity studies in lectin/ carbohydrate interactions

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Lectins are ubiquitous carbohydrate-binding proteins, characterized by their specificity recognition towards complex oligosaccharides and their non-immune origin.Their ability to distinguish oligosaccharides is central to many biological processes involving cell communication. They also play a role in many diseases being involved in cancer development and metastasis, inflammation and host-pathogen recognition. If recently characterized bacterial lectins display higher affinity for their target with Kd for monosaccharides in the micromolar range,3 lectin-carbohydrate interactions are more often characterized by rather low affinity, which is generally compensated by the presence of several binding sites, resulting in avidity or velcro effect. The development of fast and effective methods for determining lectin affinity and specificity has been hampered by the technical problem of obtaining sufficient amount of pure and well characterized oligosaccharides. Lectins are ubiquitous carbohydrate-binding proteins, characterized by their specificity recognition towards complex oligosaccharides and their non-immune origin.Their ability to distinguish oligosaccharides is central to many biological processes involving cell communication. They also play a role in many diseases being involved in cancer development and metastasis, inflammation and host-pathogen recognition. If recently characterized bacterial lectins display higher affinity for their target with Kd for monosaccharides in the micromolar range,3 lectin-carbohydrate interactions are more often characterized by rather low affinity, which is generally compensated by the presence of several binding sites, resulting in avidity or velcro effect. The development of fast and effective methods for determining lectin affinity and specificity has been hampered by the technical problem of obtaining sufficient amount of pure and well characterized oligosaccharides. (en)
Title	Specificity and affinity studies in lectin/ carbohydrate interactions Specificity and affinity studies in lectin/ carbohydrate interactions (en)
skos:prefLabel	Specificity and affinity studies in lectin/ carbohydrate interactions Specificity and affinity studies in lectin/ carbohydrate interactions (en)
skos:notation	RIV/00216224:14310/09:00035557!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC06030), Z(MSM0021622413)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Šulák, Ondřej Wimmerová, Michaela Imberty, Anne
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	342824
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/09:00035557
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lectins; ITC; SPR; fluorescence; NMR; interaction (en)
http://linked.open.../riv/klicoveSlovo	lectins NMR fluorescence interaction ITC SPR
http://linked.open...ontrolniKodProRIV	[5461704A114A]
http://linked.open...i/riv/mistoVydani	UK
http://linked.open...vEdiceCisloSvazku	SPR Carbohydrate Chemistry, Vol. 35
http://linked.open...i/riv/nazevZdroje	Carbohydrate Chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...v/pocetStranKnihy	300 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomolecular centre
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Imberty, Anne Wimmerová, Michaela Šulák, Ondřej Lameignere, Emile
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
number of pages	15 (xsd:int)
http://purl.org/ne...btex#hasPublisher	The Royal Society of Chemistry 2009
https://schema.org/isbn	978-1-84755-880-0
http://localhost/t...ganizacniJednotka	14310

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