About: Modulation of gp130 Signalling by Inhibitors of Reactive Oxygen Species Formation in Mouse Embryonic Stem Cells

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About: Modulation of gp130 Signalling by Inhibitors of Reactive Oxygen Species Formation in Mouse Embryonic Stem Cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The gp130 system is a set of ligands and receptors that dominantly involves the activation of the JAK/STAT, Erk, and PI3K/Akt pathways. gp130 is suggested to play a key role in response of stem cells to both the mediators that maintain stem cell undifferentiated phenotype and the mediators inducing differentiation. Under physiological conditions in their niche, stem cells are kept in hypoxic microenvironment. Leaving their niche they are exposed to normal levels of oxygen. Thus reactive oxygen species (ROS) formation in stem cells due to hypoxic conditions could be considered as important regulator of stem cell fate. Here we analyzed effects of inhibitors of NADPH oxidases apocynin or diphenyleneiodonium (DPI), and a glutathione precursor N-acetyl-cysteine (NAC) on activity of gp130 signaling pathways and maintenance of mouse ES cells. The obtained results are compared with effects of ES cells culture in hypoxia condition. The gp130 system is a set of ligands and receptors that dominantly involves the activation of the JAK/STAT, Erk, and PI3K/Akt pathways. gp130 is suggested to play a key role in response of stem cells to both the mediators that maintain stem cell undifferentiated phenotype and the mediators inducing differentiation. Under physiological conditions in their niche, stem cells are kept in hypoxic microenvironment. Leaving their niche they are exposed to normal levels of oxygen. Thus reactive oxygen species (ROS) formation in stem cells due to hypoxic conditions could be considered as important regulator of stem cell fate. Here we analyzed effects of inhibitors of NADPH oxidases apocynin or diphenyleneiodonium (DPI), and a glutathione precursor N-acetyl-cysteine (NAC) on activity of gp130 signaling pathways and maintenance of mouse ES cells. The obtained results are compared with effects of ES cells culture in hypoxia condition. (en)
Title	Modulation of gp130 Signalling by Inhibitors of Reactive Oxygen Species Formation in Mouse Embryonic Stem Cells Modulation of gp130 Signalling by Inhibitors of Reactive Oxygen Species Formation in Mouse Embryonic Stem Cells (en)
skos:prefLabel	Modulation of gp130 Signalling by Inhibitors of Reactive Oxygen Species Formation in Mouse Embryonic Stem Cells Modulation of gp130 Signalling by Inhibitors of Reactive Oxygen Species Formation in Mouse Embryonic Stem Cells (en)
skos:notation	RIV/00216224:14310/09:00030039!RIV11-GA0-14310___
http://linked.open...avai/riv/aktivita	P S V
http://linked.open...avai/riv/aktivity	P(GA301/08/0717), P(GD204/09/H058), S, V
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Štefková, Kateřina Procházková, Jiřina Kotasová, Hana Pacherník, Jiří Kučera, Jan
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	327184
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/09:00030039
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	stem cells; gp130; reactive oxgen species; ROS; hypoxia; redox modulators (en)
http://linked.open.../riv/klicoveSlovo	stem cells ROS gp130 hypoxia reactive oxgen species redox modulators
http://linked.open...ontrolniKodProRIV	[763D6D97F580]
http://linked.open...v/mistoKonaniAkce	San Francisco, CA, USA
http://linked.open...i/riv/mistoVydani	New York, NY, USA
http://linked.open...i/riv/nazevZdroje	FREE RADICAL BIOLOGY AND MEDICINE
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Gp130 receptor-mediated differentiation of ES cells Intercellular signalling in development and disease
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Kotasová, Hana Kubala, Lukáš Kučera, Jan Pacherník, Jiří Procházková, Jiřina Štefková, Kateřina
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open...ain/vavai/riv/wos	000271988500041
http://linked.open.../riv/zahajeniAkce	2009-11-18 (xsd:date)
issn	0891-5849
number of pages	18 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Elsevier Science
http://localhost/t...ganizacniJednotka	14310

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