About: Differences in conformational behavior of amyloid beta in solvent with different ionic strength

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About: Differences in conformational behavior of amyloid beta in solvent with different ionic strength Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	INTRODUCTION Amyloid beta-peptide (Abeta) is the major component of plaques found in the brains of Alzheimers patients. Among its two predominate forms - Abeta(1-40) and Abeta(1-42), the latter possesses stronger aggregation and deposition propensity than the former. To explore the conformational preference of Abeta(1-42) in solvent with different ionic strength, molecular dynamics (MD) simulations were performed. METHODS The human Abeta(1-42) structure presented in PDB database (code 1Z0Q) was used as starting point for MD simulations. The rat structure was prepared from human by mutation of 3 residues using Modeller software. The input structures were solvated by program SOLVATE and sodium and chloride ions in different concentrations were added to the system. For each system, 50 ns long trajectory was run and stability of the secondary structures of the protein was investigated. INTRODUCTION Amyloid beta-peptide (Abeta) is the major component of plaques found in the brains of Alzheimers patients. Among its two predominate forms - Abeta(1-40) and Abeta(1-42), the latter possesses stronger aggregation and deposition propensity than the former. To explore the conformational preference of Abeta(1-42) in solvent with different ionic strength, molecular dynamics (MD) simulations were performed. METHODS The human Abeta(1-42) structure presented in PDB database (code 1Z0Q) was used as starting point for MD simulations. The rat structure was prepared from human by mutation of 3 residues using Modeller software. The input structures were solvated by program SOLVATE and sodium and chloride ions in different concentrations were added to the system. For each system, 50 ns long trajectory was run and stability of the secondary structures of the protein was investigated. (en)
Title	Differences in conformational behavior of amyloid beta in solvent with different ionic strength Differences in conformational behavior of amyloid beta in solvent with different ionic strength (en)
skos:prefLabel	Differences in conformational behavior of amyloid beta in solvent with different ionic strength Differences in conformational behavior of amyloid beta in solvent with different ionic strength (en)
skos:notation	RIV/00216224:14310/09:00029983!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/09/0457), P(LC06030), Z(MSM0021622413)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Koča, Jaroslav Kříž, Zdeněk
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	310455
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/09:00029983
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	amyloid beta; ionic strength; molecular dynamics; conformational behavior (en)
http://linked.open.../riv/klicoveSlovo	conformational behavior ionic strength amyloid beta molecular dynamics
http://linked.open...ontrolniKodProRIV	[7464C9E57956]
http://linked.open...v/mistoKonaniAkce	Praha
http://linked.open...i/riv/mistoVydani	Oxford
http://linked.open...i/riv/nazevZdroje	34th Congress of the Federation-of-European-Biochemical-Societies
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Evaluation of the binding between cerebrosterol and amyloid beta peptide 1-40 Biomolecular centre
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Koča, Jaroslav Kříž, Zdeněk Krištofíková, Zdena
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open...ain/vavai/riv/wos	000267069900418
http://linked.open.../riv/zahajeniAkce	2009-01-01 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
issn	1742-464X
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Wiley-Blackwell
http://localhost/t...ganizacniJednotka	14310

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