About: Copper ions regulate cytotoxicity of disulfiram to myeloid leukemia cells     Goto   Sponge   NotDistinct   Permalink

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Description
  • In this study, we report the cell density-dependent induction of apoptosis of human acute myeloid leukemia U937 and ML-1 cells by disulfiram (DSF), the dithiocarbamate drug recently proposed for treatment of human cancers. This effect is dependent on uptake of extracellular copper and its intracellular accumulation.
  • In this study, we report the cell density-dependent induction of apoptosis of human acute myeloid leukemia U937 and ML-1 cells by disulfiram (DSF), the dithiocarbamate drug recently proposed for treatment of human cancers. This effect is dependent on uptake of extracellular copper and its intracellular accumulation. (en)
Title
  • Copper ions regulate cytotoxicity of disulfiram to myeloid leukemia cells
  • Copper ions regulate cytotoxicity of disulfiram to myeloid leukemia cells (en)
skos:prefLabel
  • Copper ions regulate cytotoxicity of disulfiram to myeloid leukemia cells
  • Copper ions regulate cytotoxicity of disulfiram to myeloid leukemia cells (en)
skos:notation
  • RIV/00216224:14310/09:00029462!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA203/09/1025), P(GA301/09/1115), Z(MSM0021622411), Z(MSM0021622412), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 308350
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/09:00029462
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • disulfiram; copper; myeloid leukemia; cell density; inoculum effect; SALD ICP MS (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GR - Řecká republika
http://linked.open...ontrolniKodProRIV
  • [750A01C1CFDE]
http://linked.open...i/riv/nazevZdroje
  • International Journal of Molecular Medicine
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 24
http://linked.open...iv/tvurceVysledku
  • Kanický, Viktor
  • Preisler, Jan
  • Šmarda, Jan
  • Navrátilová, Jarmila
  • Vaňhara, Petr
  • Jungová, Pavla
http://linked.open...ain/vavai/riv/wos
  • 000270497400009
http://linked.open...n/vavai/riv/zamer
issn
  • 1107-3756
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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