About: Recognition of phosphorylated CTD of RNA Pol II by Nrd1

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The transcription by RNA polymerase II (Pol II) in Saccharomyces cerevisiae can be terminated via at least two pathways - the mRNA pathway and ncRNA pathway. Both of them require interaction of CTD domain of RNA poly II with CID domain of a specialized protein. The CTD domain of RNA polymerase II contains tandem repeats of a heptad sequence that are dynamically phosphorylated or dephosphorylated on Ser5 and Ser2 over the course of transcription. The Nrd1 protein acts in ncRNA pathway - where Nrd1 (in complex with Nab3 and Sen1) is via its CID domain bound to CTD domain of RNA poly II. Depending on the extent of exosome degradation, this termination pathway can lead to either 3' end trimming or complete degradation. Unlike other factors of transcription termination, Nrd1 binds preferentially to CTD phosphorylated at Ser5, which has the highest levels of fosforylation in early elongation. The transcription by RNA polymerase II (Pol II) in Saccharomyces cerevisiae can be terminated via at least two pathways - the mRNA pathway and ncRNA pathway. Both of them require interaction of CTD domain of RNA poly II with CID domain of a specialized protein. The CTD domain of RNA polymerase II contains tandem repeats of a heptad sequence that are dynamically phosphorylated or dephosphorylated on Ser5 and Ser2 over the course of transcription. The Nrd1 protein acts in ncRNA pathway - where Nrd1 (in complex with Nab3 and Sen1) is via its CID domain bound to CTD domain of RNA poly II. Depending on the extent of exosome degradation, this termination pathway can lead to either 3' end trimming or complete degradation. Unlike other factors of transcription termination, Nrd1 binds preferentially to CTD phosphorylated at Ser5, which has the highest levels of fosforylation in early elongation. (en)
Title	Recognition of phosphorylated CTD of RNA Pol II by Nrd1 Recognition of phosphorylated CTD of RNA Pol II by Nrd1 (en)
skos:prefLabel	Recognition of phosphorylated CTD of RNA Pol II by Nrd1 Recognition of phosphorylated CTD of RNA Pol II by Nrd1 (en)
skos:notation	RIV/00216224:14310/09:00028837!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/08/1212), P(IAA401630903), P(LA08008), Z(MSM0021622413)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kubíček, Karel Štefl, Richard Černá, Hana
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	338375
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/09:00028837
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NMR; CTD; RNA; transcription termination (en)
http://linked.open.../riv/klicoveSlovo	NMR RNA CTD transcription termination
http://linked.open...ontrolniKodProRIV	[15322D309703]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Structural studies of protein-RNA complexes involved in RNA quality control Structural basis for transcription termination of nonpolyadenylated transcripts Structural studies of protein-RNA complexes involved in RNA quality control
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Černá, Hana Kubíček, Karel Štefl, Richard
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
http://localhost/t...ganizacniJednotka	14310

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