About: H3K9 Acetylation and Radial Chromatin Positioning

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We analyzed the effect of epigenetic changes induced by a histone deacetylase inhibitor (HDACi) on the nuclear radial rearrangement of select genomic regions and chromosomes. Three-dimensional analysis of nuclear radial distributions revealed that this increase in H3K9 acetylation was often associated with a repositioning of select loci and chromosomes toward the nuclear center. On the other hand, many centromeres resided sites more toward the nuclear periphery, similar to sites occupied by chromosome X. In more than two-thirds of events analyzed, central nuclear positioning correlated with a high level of H3K9 acetylation, while more peripheral positioning within interphase nuclei correlated with a lower level of acetylation. This was observed for the gene-rich chromosomes 17 and 19, TP53, and CCND / genes as well as for gene-poor chromosome 18, APC gene, regions of low transcriptional activity (anti-RIDGEs), and the relatively transcriptionally less active chromosome X. We analyzed the effect of epigenetic changes induced by a histone deacetylase inhibitor (HDACi) on the nuclear radial rearrangement of select genomic regions and chromosomes. Three-dimensional analysis of nuclear radial distributions revealed that this increase in H3K9 acetylation was often associated with a repositioning of select loci and chromosomes toward the nuclear center. On the other hand, many centromeres resided sites more toward the nuclear periphery, similar to sites occupied by chromosome X. In more than two-thirds of events analyzed, central nuclear positioning correlated with a high level of H3K9 acetylation, while more peripheral positioning within interphase nuclei correlated with a lower level of acetylation. This was observed for the gene-rich chromosomes 17 and 19, TP53, and CCND / genes as well as for gene-poor chromosome 18, APC gene, regions of low transcriptional activity (anti-RIDGEs), and the relatively transcriptionally less active chromosome X. (en)
Title	H3K9 Acetylation and Radial Chromatin Positioning H3K9 Acetylation and Radial Chromatin Positioning (en)
skos:prefLabel	H3K9 Acetylation and Radial Chromatin Positioning H3K9 Acetylation and Radial Chromatin Positioning (en)
skos:notation	RIV/00216224:14310/09:00028664!RIV11-AV0-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040508), P(GA204/06/0978), P(IAA5004306), P(LC06027), P(LC535), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Strašák, Luděk Galiová-Šustáčková, Gabriela Bártová, Eva Kozubek, Stanislav Harničarová Horáková, Andrea
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	318254
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/09:00028664
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HDACi; epigenetics (en)
http://linked.open.../riv/klicoveSlovo	epigenetics HDACi
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[FE21626138A6]
http://linked.open...i/riv/nazevZdroje	Journal of cellular physiology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Methylation of histone H3 as a prognostic marker of chronic myeloid leukemia remission Chromosome dynamics and organization during the cell cycle in normal and pathologic conditions University Research Centre - Czech Myeloma Group Postranslational modifications of histones after cell treatment by inhibitors of histone deacetylases and during induction of cell differentiation Human genome structure
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	220
http://linked.open...iv/tvurceVysledku	Bártová, Eva Kozubek, Stanislav Krejčí, Jana Strašák, Luděk Galiová, Gabriela Harničarová, Andrea
http://linked.open...ain/vavai/riv/wos	000266672400011
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0021-9541
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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