About: CXXC5 is a novel BMP4-regulated modulator of Wnt-signaling in neural stem cells

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About: CXXC5 is a novel BMP4-regulated modulator of Wnt-signaling in neural stem cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In a screen designed to identify novel targets of BMP4 signaling in telencephalic neural stem cells, we found that the levels of the previously uncharacterized factor CXXC5 were reproducibly up-regulated after BMP4 stimulation. We demonstrate that CXXC5 can interact with the Wnt-signaling intermediate Dishevelled and attenuate Wnt signalling. We conclude that CXXC5 is a BMP4-induced inhibitor of Wnt signaling in neural progenitors. In a screen designed to identify novel targets of BMP4 signaling in telencephalic neural stem cells, we found that the levels of the previously uncharacterized factor CXXC5 were reproducibly up-regulated after BMP4 stimulation. We demonstrate that CXXC5 can interact with the Wnt-signaling intermediate Dishevelled and attenuate Wnt signalling. We conclude that CXXC5 is a BMP4-induced inhibitor of Wnt signaling in neural progenitors. (en)
Title	CXXC5 is a novel BMP4-regulated modulator of Wnt-signaling in neural stem cells CXXC5 is a novel BMP4-regulated modulator of Wnt-signaling in neural stem cells (en)
skos:prefLabel	CXXC5 is a novel BMP4-regulated modulator of Wnt-signaling in neural stem cells CXXC5 is a novel BMP4-regulated modulator of Wnt-signaling in neural stem cells (en)
skos:notation	RIV/00216224:14310/09:00028452!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(KJB501630801), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Bryja, Vítězslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	308758
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/09:00028452
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Wnt signalling; CXXC5; neural stem cells (en)
http://linked.open.../riv/klicoveSlovo	CXXC5 Wnt signalling neural stem cells
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D1A8343ACB2E]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Posttranslational modification of Dishevelled
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	284
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Červenka, Igor Andersson, Therese Cascante, Anna Duckworth K., Joshua Fritz, Nicolas Hermanson, Ola Sacchetti, Paola Södersten, Erik
http://linked.open...ain/vavai/riv/wos	000262872500035
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	0021-9258
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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