About: Identification of somatic hypermutations in the TP53 gene in B-cell chronic lymphocytic leukemia

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About: Identification of somatic hypermutations in the TP53 gene in B-cell chronic lymphocytic leukemia Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	B-cell chronic lymphocytic leukemia is a malignant disease of elderly individuals with highly variable clinical course. Aberrations of TP53 gene together with mutational status of immunoglobulin heavy chain variable region (IgVH) are the most important prognostic factors. Here we report identification of two patients harbouring mutational mosaic of TP53 gene in their leukemic cells using FASAY methodology. On the basis of nucleotide and sequence targeting of the mutations, we can hypothesize, that the IgVH-directed hypermutation machinery is most likely responsible for these multiple TP53 mutations. This process is initiated by activation-induced cytidine deaminase, and in the case of deregulation can be targeted outside the IgVH locus resulting in tumorigenesis. This is the fist report of such TP53 mosaic in B-CLL patients. B-cell chronic lymphocytic leukemia is a malignant disease of elderly individuals with highly variable clinical course. Aberrations of TP53 gene together with mutational status of immunoglobulin heavy chain variable region (IgVH) are the most important prognostic factors. Here we report identification of two patients harbouring mutational mosaic of TP53 gene in their leukemic cells using FASAY methodology. On the basis of nucleotide and sequence targeting of the mutations, we can hypothesize, that the IgVH-directed hypermutation machinery is most likely responsible for these multiple TP53 mutations. This process is initiated by activation-induced cytidine deaminase, and in the case of deregulation can be targeted outside the IgVH locus resulting in tumorigenesis. This is the fist report of such TP53 mosaic in B-CLL patients. (en)
Title	Identification of somatic hypermutations in the TP53 gene in B-cell chronic lymphocytic leukemia Identification of somatic hypermutations in the TP53 gene in B-cell chronic lymphocytic leukemia (en)
skos:prefLabel	Identification of somatic hypermutations in the TP53 gene in B-cell chronic lymphocytic leukemia Identification of somatic hypermutations in the TP53 gene in B-cell chronic lymphocytic leukemia (en)
skos:notation	RIV/00216224:14310/08:00028197!RIV10-MZ0-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NR8445), P(NR8448), P(NR9305)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kotašková, Jana Pospíšilová, Šárka Dvořáková, Dana Brychtová, Yvona Doubek, Michael Mayer, Jiří Tichý, Boris Šmardová, Jana Malčíková, Jitka Trbušek, Martin Čejková, Soňa
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	371266
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00028197
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	B cell chronic lymphocytic leukemia; TP53; FASAY; Somatic hypermutation; Activation induced cytidine deaminase (en)
http://linked.open.../riv/klicoveSlovo	Somatic hypermutation FASAY TP53 Activation induced cytidine deaminase B cell chronic lymphocytic leukemia
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[EEF35F48EB79]
http://linked.open...i/riv/nazevZdroje	Molecular Immunology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	11 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...vavai/riv/projekt	In vitro sensitivity/resistance of CLL cells with inactivated p53 on modern therapy Characterization of leukemia cell gene expression using DNA microarrays and its utilization for molecular diagnostics and therapy response prediction Complex analysis of p53 tumor suppressor in non-Hodgkin´s lymphomas
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	45
http://linked.open...iv/tvurceVysledku	Brychtová, Yvona Doubek, Michael Dvořáková, Dana Mayer, Jiří Peková, Soňa Pospíšilová, Šárka Tichý, Boris Malčíková, Jitka Trbušek, Martin Šmardová, Jana Francová, Hana Kotašková, Jana Čejková, Soňa Janek, Daniel
http://linked.open...ain/vavai/riv/wos	000253030000036
issn	0161-5890
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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