About: Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Many aspects of plant development, including patterning and tropisms, are largely dependent on the asymmetric distribution of the plant signaling molecule auxin. Auxin transport inhibitors (ATIs), which interfere with directional auxin transport, have been essential tools in formulating this concept. However, despite the use of ATIs in plant research for many decades, the mechanism of ATI action has remained largely elusive. Using real-time live-cell microscopy, we show here that prominent ATIs such as 2,3,5-triiodobenzoic acid (TIBA) and 2-(1-pyrenoyl) benzoic acid (PBA) inhibit vesicle trafficking in plant, yeast, and mammalian cells. Effects on micropinocytosis, rab5-labeled endosomal motility at the periphery of HeLa cells and on fibroblast mobility indicate that ATIs influence actin cytoskeleton. Visualization of actin cytoskeleton dynamics in plants, yeast, and mammalian cells show that ATIs stabilize actin. Many aspects of plant development, including patterning and tropisms, are largely dependent on the asymmetric distribution of the plant signaling molecule auxin. Auxin transport inhibitors (ATIs), which interfere with directional auxin transport, have been essential tools in formulating this concept. However, despite the use of ATIs in plant research for many decades, the mechanism of ATI action has remained largely elusive. Using real-time live-cell microscopy, we show here that prominent ATIs such as 2,3,5-triiodobenzoic acid (TIBA) and 2-(1-pyrenoyl) benzoic acid (PBA) inhibit vesicle trafficking in plant, yeast, and mammalian cells. Effects on micropinocytosis, rab5-labeled endosomal motility at the periphery of HeLa cells and on fibroblast mobility indicate that ATIs influence actin cytoskeleton. Visualization of actin cytoskeleton dynamics in plants, yeast, and mammalian cells show that ATIs stabilize actin. (en)
Title	Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes (en)
skos:prefLabel	Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes (en)
skos:notation	RIV/00216224:14310/08:00027622!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/05/0838), P(IAA601630703), P(KJB600380604), P(LC06034), Z(AV0Z50200510), Z(AV0Z50380511), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Friml, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	357494
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00027622
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PIN proteins; plant development; vesicle traffic; auxin efflux inhibitors (en)
http://linked.open.../riv/klicoveSlovo	plant development PIN proteins auxin efflux inhibitors vesicle traffic
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[454E3796B7A3]
http://linked.open...i/riv/nazevZdroje	Proceedings of the National Academy of Sciences of the United States of America
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	20 (xsd:int)
http://linked.open...vavai/riv/projekt	Identification of molecular components and the mechanism of polar targeting of PIN auxin transport proteins in Arabidopsis thaliana Regulation of morphogenesis of plant cells and organs Role of eIF3a/Rpg1p in reassembly of microtubules and stress response in yeast Mechanisms of intracellular trafficking and polar targeting of auxin efflux facilitators.
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	105
http://linked.open...iv/tvurceVysledku	Friml, Jiří Petrášek, Jan Zažímalová, Eva Tejos, Ricardo Hašek, Jiří Seifertová, Daniela Akhmanova, Anna Brock, Roland Dhonukshe, Pankaj Fischer, Rainer Gadella, Jr, Theodorus W. J. Grigoriev, Ilya Meiselm, Lee A. Oiwa, Kazuhiro Paciorek, Tomasz Robinson, David G Spang, Anne Stierhof, York-Dieter Tominaga, Motoki Ueda, Takashi
http://linked.open...ain/vavai/riv/wos	000254263300074
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy Molecular basis of cell and tissue regulations
issn	0027-8424
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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