About: Role of interaction od Rad54 with Mus81/MMS4 during DNA repair     Goto   Sponge   NotDistinct   Permalink

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  • The Saccharomyces cerevisae Mus81-Mms4 protein complex, a DNA structure-specific endonuclease, helps preserve genomic integrity by resolving pathological DNA structures that arise from damaged or aborted replication forks and may also play a role in the resolution of DNA intermediates arising through homologous recombination. Previous yeast two-hybrid studies have found an interaction of the Mus81 protein with Rad54, a Swi2/Snf2-like factor that serves multiple roles in homologous recombination processes, but the functional significance of this novel interaction remains unknown. Here, using highly purified S. cerevisiae proteins, we show that Rad54 strongly stimulates the Mus81-Mms4 nuclease activity on a broad range of DNA substrates. This nuclease enhancement does not require ATP binding nor its hydrolysis by Rad54. We present evidence that Rad54 acts by targeting Mus81-Mms4 complex to its DNA substrates.
  • The Saccharomyces cerevisae Mus81-Mms4 protein complex, a DNA structure-specific endonuclease, helps preserve genomic integrity by resolving pathological DNA structures that arise from damaged or aborted replication forks and may also play a role in the resolution of DNA intermediates arising through homologous recombination. Previous yeast two-hybrid studies have found an interaction of the Mus81 protein with Rad54, a Swi2/Snf2-like factor that serves multiple roles in homologous recombination processes, but the functional significance of this novel interaction remains unknown. Here, using highly purified S. cerevisiae proteins, we show that Rad54 strongly stimulates the Mus81-Mms4 nuclease activity on a broad range of DNA substrates. This nuclease enhancement does not require ATP binding nor its hydrolysis by Rad54. We present evidence that Rad54 acts by targeting Mus81-Mms4 complex to its DNA substrates. (en)
Title
  • Role of interaction od Rad54 with Mus81/MMS4 during DNA repair
  • Role of interaction od Rad54 with Mus81/MMS4 during DNA repair (en)
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  • Role of interaction od Rad54 with Mus81/MMS4 during DNA repair
  • Role of interaction od Rad54 with Mus81/MMS4 during DNA repair (en)
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  • RIV/00216224:14310/08:00026762!RIV10-MSM-14310___
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  • Z(MSM 143100005), Z(MSM0021622413)
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  • RIV/00216224:14310/08:00026762
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  • DNA repair; homologous recombination; nuclease activity; MUS81; Rad54 (en)
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  • Matulová, Petra
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  • 14310
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