About: Role of SRS2 and Mus81/MMS4 in processing recombination/replication intermediates .     Goto   Sponge   NotDistinct   Permalink

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  • www.gmi.oeaw.ac.at
Description
  • Homologous recombination (HR) is a process widespread in nature and essential to maintain the integrity of the genome via repair of DNA double-strand breaks (DSBs). Several models were proposed to understand the mechanism of double-strand break repair by HR, identify separate steps and role of the individual proteins involved. The Mus81/MMS4 complex is a DNA structure-specific endonuclease involved in replication fork stability and DNA repair. It seems from genetic experiments that Mus81/MMS4 could interact with Srs2, a helicase which on one hand prevents untimely recombination and on the other hand is necessary for certain pathways of homologous recombination. In our study, we confirmed the interaction between Mus81/MMS4 and Srs2. We then analyzed the stimulation of Mus81/MMS4 nuclease activity by Srs2 and we found out that this stimulation depends on the DNA subtrate involved in the reaction. Our experiments also indicate that the interaction between Mus81/MMS4 and Srs2 is specific.
  • Homologous recombination (HR) is a process widespread in nature and essential to maintain the integrity of the genome via repair of DNA double-strand breaks (DSBs). Several models were proposed to understand the mechanism of double-strand break repair by HR, identify separate steps and role of the individual proteins involved. The Mus81/MMS4 complex is a DNA structure-specific endonuclease involved in replication fork stability and DNA repair. It seems from genetic experiments that Mus81/MMS4 could interact with Srs2, a helicase which on one hand prevents untimely recombination and on the other hand is necessary for certain pathways of homologous recombination. In our study, we confirmed the interaction between Mus81/MMS4 and Srs2. We then analyzed the stimulation of Mus81/MMS4 nuclease activity by Srs2 and we found out that this stimulation depends on the DNA subtrate involved in the reaction. Our experiments also indicate that the interaction between Mus81/MMS4 and Srs2 is specific. (en)
Title
  • Role of SRS2 and Mus81/MMS4 in processing recombination/replication intermediates .
  • Role of SRS2 and Mus81/MMS4 in processing recombination/replication intermediates . (en)
skos:prefLabel
  • Role of SRS2 and Mus81/MMS4 in processing recombination/replication intermediates .
  • Role of SRS2 and Mus81/MMS4 in processing recombination/replication intermediates . (en)
skos:notation
  • RIV/00216224:14310/08:00026760!RIV10-MSM-14310___
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  • RIV/00216224:14310/08:00026760
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  • DNA repair; homologous recombination; nuclease activity; MUS81; SRS2 (en)
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  • Matulová, Petra
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  • 14310
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