About: Interaction with RPA Is Necessary for Rad52 Repair Center Formation and for Its Mediator Activity.

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About: Interaction with RPA Is Necessary for Rad52 Repair Center Formation and for Its Mediator Activity. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Homologous recombination (HR) is a major DNA repair pathway and therefore essential for maintaining the integrity of the genome. HR is catalyzed by proteins encoded by genes of the RAD52 epistasis group, including the recombinase Rad51 and its mediator Rad52. HR proteins fused with green fluorescent protein form foci at damaged DNA reflecting the assembly of repair centers that harbor a high concentration of repair proteins. Rad52 mediates the recruitment of Rad51 and other HR proteins to DNA damage. To understand the mechanism for the assembly of Rad52-dependent DNA repair centers, we used a mutational strategy to identify a Rad52 domain essential for its recruitment to DNA repair foci. We present evidence to implicate an acidic domain in Rad52 in DNA repair focus formation. Mutations in this domain confer marked DNA damage sensitivity and recombination deficiency. Importantly, these Rad52 mutants are specifically compromised for interaction with the single-stranded DNA-binding factor RPA. Homologous recombination (HR) is a major DNA repair pathway and therefore essential for maintaining the integrity of the genome. HR is catalyzed by proteins encoded by genes of the RAD52 epistasis group, including the recombinase Rad51 and its mediator Rad52. HR proteins fused with green fluorescent protein form foci at damaged DNA reflecting the assembly of repair centers that harbor a high concentration of repair proteins. Rad52 mediates the recruitment of Rad51 and other HR proteins to DNA damage. To understand the mechanism for the assembly of Rad52-dependent DNA repair centers, we used a mutational strategy to identify a Rad52 domain essential for its recruitment to DNA repair foci. We present evidence to implicate an acidic domain in Rad52 in DNA repair focus formation. Mutations in this domain confer marked DNA damage sensitivity and recombination deficiency. Importantly, these Rad52 mutants are specifically compromised for interaction with the single-stranded DNA-binding factor RPA. (en)
Title	Interaction with RPA Is Necessary for Rad52 Repair Center Formation and for Its Mediator Activity. Interaction with RPA Is Necessary for Rad52 Repair Center Formation and for Its Mediator Activity. (en)
skos:prefLabel	Interaction with RPA Is Necessary for Rad52 Repair Center Formation and for Its Mediator Activity. Interaction with RPA Is Necessary for Rad52 Repair Center Formation and for Its Mediator Activity. (en)
skos:notation	RIV/00216224:14310/08:00026744!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC06030), P(ME 888), Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika	283
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Krejčí, Lumír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	372820
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00026744
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Rad52; recombination mediator; DNA repair (en)
http://linked.open.../riv/klicoveSlovo	DNA repair Rad52 recombination mediator
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1AF309663B46]
http://linked.open...i/riv/nazevZdroje	J. Biol. Chem.
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomolecular centre http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20888
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Krejčí, Lumír Sung, Patrick Albertsen, L. Hallwyl, SC Mortensen, Uffe Muller, C. Plate, Iben Shi, Idina
http://linked.open...ain/vavai/riv/wos	000260179900035
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
issn	0021-9258
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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