About: Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52     Goto   Sponge   NotDistinct   Permalink

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  • A helical filament of Rad51 on single-strand DNA (ssDNA), called the presynaptic filament, catalyzes DNA joint formation during homologous recombination. Rad52 facilitates presynaptic filament assembly, and this recombination mediator activity is thought to rely on the interactions of Rad52 with Rad51, the ssDNA-binding protein RPA, and ssDNA. The N-terminal region of Rad52, which has DNA binding activity and an oligomeric structure, is thought to be crucial for mediator activity and recombination. Unexpectedly, we find that the C-terminal region of Rad52 also harbors a DNA binding function. Importantly, the Rad52 C-terminal portion alone can promote Rad51 presynaptic filament assembly. The middle portion of Rad52 associates with DNA-bound RPA and contributes to the recombination mediator activity.
  • A helical filament of Rad51 on single-strand DNA (ssDNA), called the presynaptic filament, catalyzes DNA joint formation during homologous recombination. Rad52 facilitates presynaptic filament assembly, and this recombination mediator activity is thought to rely on the interactions of Rad52 with Rad51, the ssDNA-binding protein RPA, and ssDNA. The N-terminal region of Rad52, which has DNA binding activity and an oligomeric structure, is thought to be crucial for mediator activity and recombination. Unexpectedly, we find that the C-terminal region of Rad52 also harbors a DNA binding function. Importantly, the Rad52 C-terminal portion alone can promote Rad51 presynaptic filament assembly. The middle portion of Rad52 associates with DNA-bound RPA and contributes to the recombination mediator activity. (en)
Title
  • Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52
  • Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52 (en)
skos:prefLabel
  • Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52
  • Molecular anatomy of the recombination mediator function of Saccharomyces cerevisiae Rad52 (en)
skos:notation
  • RIV/00216224:14310/08:00026743!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(LC06030), P(ME 888), Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika
  • 283
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  • 380317
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  • RIV/00216224:14310/08:00026743
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  • Rad52; recombination mediator; DNA repair (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [A047E1ACD805]
http://linked.open...i/riv/nazevZdroje
  • J. Biol. Chem.
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  • 18
http://linked.open...iv/tvurceVysledku
  • Krejčí, Lumír
  • Sung, Patrick
  • Mortensen, Uffe
  • Plate, Iben
  • Shi, Idina
  • Chi, Peter
  • Sehorn, Michael
  • Seong, Changhyuan
  • Song, Binway
http://linked.open...ain/vavai/riv/wos
  • 000255340000033
http://linked.open...n/vavai/riv/zamer
issn
  • 0021-9258
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  • 14310
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