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  • We synthesized several theophylline analogs and tested the hypothesis that these compounds may be nootropic or cognitive enhancers by examining their effects on evoked population spikes recorded extracellularly in the CA1 region of the rat hippocampus. Whereas the length of the carbon chain on N7 had no effect, different size of the terminal lactam ring strongly influenced neuroactivity. Our results suggest that hexahydroazepin-2-one analogs have potential for further development as cognitive enhancers.
  • We synthesized several theophylline analogs and tested the hypothesis that these compounds may be nootropic or cognitive enhancers by examining their effects on evoked population spikes recorded extracellularly in the CA1 region of the rat hippocampus. Whereas the length of the carbon chain on N7 had no effect, different size of the terminal lactam ring strongly influenced neuroactivity. Our results suggest that hexahydroazepin-2-one analogs have potential for further development as cognitive enhancers. (en)
Title
  • Synthesis and structure_activity relationship studies of theophylline analogs
  • Synthesis and structure_activity relationship studies of theophylline analogs (en)
skos:prefLabel
  • Synthesis and structure_activity relationship studies of theophylline analogs
  • Synthesis and structure_activity relationship studies of theophylline analogs (en)
skos:notation
  • RIV/00216224:14310/08:00026369!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(LC06030), Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika
  • 17
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 398753
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/08:00026369
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Hippocampus; Acetylcholine receptors; Dementia; Nootropic; Theophylline analogs (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [D40B05DFD3E3]
http://linked.open...i/riv/nazevZdroje
  • Bioorganic & Medicinal Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 16
http://linked.open...iv/tvurceVysledku
  • Beneš, Luděk
  • Marek, Radek
  • Novotný, Ladislav
  • Bartl, Tomáš
  • Ananthalakshmi, Kethireddy V. V.
  • Aziza, Mohammed H.
  • Kombian, Samuel B.
http://linked.open...ain/vavai/riv/wos
  • 000258827800032
http://linked.open...n/vavai/riv/zamer
issn
  • 0968-0896
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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