About: NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives

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About: NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Substituted pyrazolopyridines are potent inhibitors of phosphodiesterases and cyclin-dependent kinases. In this study, NMR was used to investigate the potential N1-H and N2-H tautomerism of 5-substituted pyrazolo[3,4-c]pyridine derivatives. Six compounds were fully characterized by using 1H, 13C, and 15N chemical shifts and indirect 1H-13C and 1H-15N coupling constants. The 1H NMR spectra were measured over a broad range of temperatures. All of the compounds were shown to exist predominantly in the N1-H tautomeric form. Complementary quantum-chemical calculations of the chemical shieldings and indirect spin-spin couplings support the structural conclusions drawn. Substituted pyrazolopyridines are potent inhibitors of phosphodiesterases and cyclin-dependent kinases. In this study, NMR was used to investigate the potential N1-H and N2-H tautomerism of 5-substituted pyrazolo[3,4-c]pyridine derivatives. Six compounds were fully characterized by using 1H, 13C, and 15N chemical shifts and indirect 1H-13C and 1H-15N coupling constants. The 1H NMR spectra were measured over a broad range of temperatures. All of the compounds were shown to exist predominantly in the N1-H tautomeric form. Complementary quantum-chemical calculations of the chemical shieldings and indirect spin-spin couplings support the structural conclusions drawn. (en)
Title	NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives (en)
skos:prefLabel	NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives (en)
skos:notation	RIV/00216224:14310/08:00025874!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC06030), Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Bartl, Tomáš Toušek, Jaromír Marek, Radek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	382797
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00025874
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NMR; 1H; 13C; 15N; tautomerism; spin-spin coupling constant; purine; pyrazolo[3.4-c]pyridine; quantum-chemical calculation (en)
http://linked.open.../riv/klicoveSlovo	15N purine NMR tautomerism 13C 1H quantum-chemical calculation pyrazolo[3.4-c]pyridine spin-spin coupling constant
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[75872CDA38B2]
http://linked.open...i/riv/nazevZdroje	Magnetic Resonance in Chemistry
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomolecular centre
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	46
http://linked.open...iv/tvurceVysledku	Marek, Radek Bartl, Tomáš Toušek, Jaromír Marakos, Panagiotis Pouli, Nicole Lougiakis, Nikolaos Mikros, Emmanuel Tite, Tony Tsikouris, Orestis
http://linked.open...ain/vavai/riv/wos	000257052400005
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
issn	0749-1581
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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