About: Analysis of transactivation capability and conformation of p53 temperature-dependent mutants and their reactivation by amifostine in yeast

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About: Analysis of transactivation capability and conformation of p53 temperature-dependent mutants and their reactivation by amifostine in yeast Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The p53 gene is often mutated during cancer development. Frequency and functional consequences of these mutations vary in different tumor types. We analyzed conformation and temperature dependency of 23 partially inactivating temperature-dependent (td) p53 mutants derived from various human tumors in yeast. We found considerable differences in transactivation capabilities and discriminative character of various p53 mutants. No correlations in transactivation rates and conformations of the td p53 proteins were detected. Amifostine-induced p53 reactivation occurred only in 13 of 23 td mutants, and this effect was temperature-dependent and responsive element-specific. The most of the p53 mutations (10/13) reactivated by amifostine were located in the part of the p53 gene coding for hydrophobic beta-sandwich structure of the DNA-binding domain. The p53 gene is often mutated during cancer development. Frequency and functional consequences of these mutations vary in different tumor types. We analyzed conformation and temperature dependency of 23 partially inactivating temperature-dependent (td) p53 mutants derived from various human tumors in yeast. We found considerable differences in transactivation capabilities and discriminative character of various p53 mutants. No correlations in transactivation rates and conformations of the td p53 proteins were detected. Amifostine-induced p53 reactivation occurred only in 13 of 23 td mutants, and this effect was temperature-dependent and responsive element-specific. The most of the p53 mutations (10/13) reactivated by amifostine were located in the part of the p53 gene coding for hydrophobic beta-sandwich structure of the DNA-binding domain. (en)
Title	Analysis of transactivation capability and conformation of p53 temperature-dependent mutants and their reactivation by amifostine in yeast Analysis of transactivation capability and conformation of p53 temperature-dependent mutants and their reactivation by amifostine in yeast (en)
skos:prefLabel	Analysis of transactivation capability and conformation of p53 temperature-dependent mutants and their reactivation by amifostine in yeast Analysis of transactivation capability and conformation of p53 temperature-dependent mutants and their reactivation by amifostine in yeast (en)
skos:notation	RIV/00216224:14310/08:00025618!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC06010), P(NR8068), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Grochová, Diana Ravčuková, Barbora Vojtěšek, Bořivoj Damborský, Jiří Šmarda, Jan Šmardová, Jana Vaňková, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	355944
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00025618
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	p53; FASAY; transactivation; conformation; temperature-dependent mutants; discriminating mutants (en)
http://linked.open.../riv/klicoveSlovo	transactivation conformation p53 FASAY discriminating mutants temperature-dependent mutants
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[FF59150E7FAD]
http://linked.open...i/riv/nazevZdroje	Oncogene
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Biocatalysis and Biotransformation Functional analysis of temperature sensitive mutants of tumor suppressor p53
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Damborský, Jiří Ravčuková, Barbora Vojtěšek, Bořivoj Šmarda, Jan Šmardová, Jana Slováčková, Jana Grochová, Diana
http://linked.open...ain/vavai/riv/wos	000253407000006
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	0950-9232
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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