About: Interference of PAHs and their N-heterocyclic analogs with signaling of retinoids.

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About: Interference of PAHs and their N-heterocyclic analogs with signaling of retinoids. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Interference of PAHs and their N-heterocyclic analogs with signaling of retinoids. Retinoids are dietary hormones acting through nuclear receptors for retinoic acid, important especially during embryonic development. This study focuses on the disruption of signaling pathways of retinoids by polycyclic aromatic hydrocarbons (PAHs) and their N-heterocyclic analogs (N-PAHs), important environmental contaminants with numerous biological effects. In vitro test with P19/A15 cell line stably transfected with luciferase reporter gene under control of retinoic acid responsive elements was used to investigate both direct activation of retinoic acid receptors and modulation of response induced by natural ligand all-trans-retinoic acid (ATRA) by 26 PAHs and N-PAHs. While none of individual compounds alone activated retinoic acid receptors, many of them modulated ATRA-mediated activity both after 6 h and 24 h exposure. Interference of PAHs and their N-heterocyclic analogs with signaling of retinoids. Retinoids are dietary hormones acting through nuclear receptors for retinoic acid, important especially during embryonic development. This study focuses on the disruption of signaling pathways of retinoids by polycyclic aromatic hydrocarbons (PAHs) and their N-heterocyclic analogs (N-PAHs), important environmental contaminants with numerous biological effects. In vitro test with P19/A15 cell line stably transfected with luciferase reporter gene under control of retinoic acid responsive elements was used to investigate both direct activation of retinoic acid receptors and modulation of response induced by natural ligand all-trans-retinoic acid (ATRA) by 26 PAHs and N-PAHs. While none of individual compounds alone activated retinoic acid receptors, many of them modulated ATRA-mediated activity both after 6 h and 24 h exposure. (en)
Title	Interference of PAHs and their N-heterocyclic analogs with signaling of retinoids. Interference of PAHs and their N-heterocyclic analogs with signaling of retinoids. (en)
skos:prefLabel	Interference of PAHs and their N-heterocyclic analogs with signaling of retinoids. Interference of PAHs and their N-heterocyclic analogs with signaling of retinoids. (en)
skos:notation	RIV/00216224:14310/08:00025289!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(2B08036), P(GP525/05/P160), S, Z(MSM0021622412)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Beníšek, Martin Bláha, Luděk Hilscherová, Klára
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	372904
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00025289
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	retinoids; PAHs; N-PAHs; quantitative structure-activity relationship (en)
http://linked.open.../riv/klicoveSlovo	PAHs retinoids N-PAHs quantitative structure-activity relationship
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[13119E4E2DC9]
http://linked.open...i/riv/nazevZdroje	Toxicology in vitro
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	New molecular biology and biochemical methods to monitor estrogens and other endocrine disruptors in the environment of the C.R. In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	22
http://linked.open...iv/tvurceVysledku	Bláha, Luděk Hilscherová, Klára Beníšek, Martin
http://linked.open...ain/vavai/riv/wos	000261583800014
http://linked.open...n/vavai/riv/zamer	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)
issn	0887-2333
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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