About: Physiological effects of humic substances

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Physiological effects of humic substances - danger or benefit? Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Humic substances (HS) represent ubiquitous products of dead organic matter decomposition. In vivo experiments on fish have shown induction of biotransformation enzyme CYP1A, a biomarker of aryl hydrocarbon receptor (AhR) activation after exposure to HS. Similarly to last referenced study, we have examined interaction of HS with AhR, i.e. receptor that mediates toxic effects of such compounds like PCDDs, PCDFs, PCBs (so called dioxin-like compounds) and PAHs. Using in vitro bioassay, we have found significant AhR-mediated activities of four out of twelve HS tested. Applied bioassay is based on H4IIE-luc cells (rat hepatoma) stably transfected with a luciferase reporter gene under the control of dioxin-responsive element. In recent contribution, we summarize our new findings on interaction of AhR-active HS, being partial agonists of AhR, with full agonists of AhR, e.g. 2,3,7,8-TCDD. Supposed ecological consequences of our findings, and the scheduled research in the field of HS will be discussed. Humic substances (HS) represent ubiquitous products of dead organic matter decomposition. In vivo experiments on fish have shown induction of biotransformation enzyme CYP1A, a biomarker of aryl hydrocarbon receptor (AhR) activation after exposure to HS. Similarly to last referenced study, we have examined interaction of HS with AhR, i.e. receptor that mediates toxic effects of such compounds like PCDDs, PCDFs, PCBs (so called dioxin-like compounds) and PAHs. Using in vitro bioassay, we have found significant AhR-mediated activities of four out of twelve HS tested. Applied bioassay is based on H4IIE-luc cells (rat hepatoma) stably transfected with a luciferase reporter gene under the control of dioxin-responsive element. In recent contribution, we summarize our new findings on interaction of AhR-active HS, being partial agonists of AhR, with full agonists of AhR, e.g. 2,3,7,8-TCDD. Supposed ecological consequences of our findings, and the scheduled research in the field of HS will be discussed. (en)
Title	Physiological effects of humic substances - danger or benefit? Physiological effects of humic substances - danger or benefit? (en)
skos:prefLabel	Physiological effects of humic substances - danger or benefit? Physiological effects of humic substances - danger or benefit? (en)
skos:notation	RIV/00216224:14310/08:00025284!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GP525/08/P464), S, Z(MSM0021622412)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Bittner, Michal Hilscherová, Klára
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	386641
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00025284
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	humic substances; Ah receptor; dioxin; interaction; agonist (en)
http://linked.open.../riv/klicoveSlovo	dioxin Ah receptor humic substances interaction agonist
http://linked.open...ontrolniKodProRIV	[E564E25EB355]
http://linked.open...v/mistoKonaniAkce	Ostrava
http://linked.open...i/riv/mistoVydani	Ostrava
http://linked.open...i/riv/nazevZdroje	Environmental changes and biological assessment IV. Scripta Facultatis Rerum Naturalium Universitatis Ostraviensis Nr. 391
http://linked.open...in/vavai/riv/obor	DJ
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Interaction of humic substances and UV-VIS irradiation with dioxin-like environmental pollutants
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Hilscherová, Klára Bittner, Michal Giesy, John P.
http://linked.open...vavai/riv/typAkce	EUR - Evropská
http://linked.open.../riv/zahajeniAkce	2008-04-10 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)
number of pages	4 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Ostravská univerzita v Ostravě
https://schema.org/isbn	978-80-7368-451-8
http://localhost/t...ganizacniJednotka	14310

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 47 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software