About: In Silico and In Vitro Mutagenesis of PA-IIL Lectin - Correlation with Structure-Function Analysis     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • Protein-carbohydrate interactions play a crucial role in recognition and adhesion of pathogen to host tissue cells in the first step of their invasion and infectivity. Pseudomonas aeruginosa is an opportunistic pathogen, responsible for numerous nosocomial infections in immunocompromised patients. The bacterium colonises patients with chronic lung diseases and its infections is fatal in cystic fibrosis patients. P. aeruginosa produces a fucose-binding lectin PA-IIL that plays a role in virulence and adhesion [1]. Similar lectins have been found in other opportunistic bacteria like Ralstonia solanacearum [2], Chromobacterium violaceaum [3] and Burkholderia cenocepacia [4], with different binding preferences despite only slight sequence changes. Mutations of the PA-IIL lectin were designed according to these differences, cloned/modelled and investigated both in vitro, and in silico [5,6].
  • Protein-carbohydrate interactions play a crucial role in recognition and adhesion of pathogen to host tissue cells in the first step of their invasion and infectivity. Pseudomonas aeruginosa is an opportunistic pathogen, responsible for numerous nosocomial infections in immunocompromised patients. The bacterium colonises patients with chronic lung diseases and its infections is fatal in cystic fibrosis patients. P. aeruginosa produces a fucose-binding lectin PA-IIL that plays a role in virulence and adhesion [1]. Similar lectins have been found in other opportunistic bacteria like Ralstonia solanacearum [2], Chromobacterium violaceaum [3] and Burkholderia cenocepacia [4], with different binding preferences despite only slight sequence changes. Mutations of the PA-IIL lectin were designed according to these differences, cloned/modelled and investigated both in vitro, and in silico [5,6]. (en)
Title
  • In Silico and In Vitro Mutagenesis of PA-IIL Lectin - Correlation with Structure-Function Analysis
  • In Silico and In Vitro Mutagenesis of PA-IIL Lectin - Correlation with Structure-Function Analysis (en)
skos:prefLabel
  • In Silico and In Vitro Mutagenesis of PA-IIL Lectin - Correlation with Structure-Function Analysis
  • In Silico and In Vitro Mutagenesis of PA-IIL Lectin - Correlation with Structure-Function Analysis (en)
skos:notation
  • RIV/00216224:14310/08:00025133!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA303/06/0570), Z(MSM0021622413)
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 371755
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/08:00025133
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Lectins; computational chemistry; molecular docking; in silico mutagenesis (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [96CBDDFA47DF]
http://linked.open...v/mistoKonaniAkce
  • Sydney
http://linked.open...i/riv/mistoVydani
  • Sydney
http://linked.open...i/riv/nazevZdroje
  • Proceedings of the Eighth Triennial Congress of the World Association of Theoretical and Computational Chemists (WATOC 2008)
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...iv/tvurceVysledku
  • Adam, Jan
  • Koča, Jaroslav
  • Pokorná, Martina
  • Wimmerová, Michaela
  • Prokop, Martin
  • Kříž, Zdeněk
http://linked.open...vavai/riv/typAkce
http://linked.open.../riv/zahajeniAkce
http://linked.open...n/vavai/riv/zamer
number of pages
http://purl.org/ne...btex#hasPublisher
  • World Association of Theoretical and Computational Chemists
https://schema.org/isbn
  • 978-0-646-50151-2
http://localhost/t...ganizacniJednotka
  • 14310
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software