About: DECIPHERING THE SUGAR PREFERENCE RULES - COMPUTER-ASSISTED PROTEIN ENGINEERING OF BACTERIAL LECTIN PA-IIL

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: DECIPHERING THE SUGAR PREFERENCE RULES - COMPUTER-ASSISTED PROTEIN ENGINEERING OF BACTERIAL LECTIN PA-IIL Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Lectin-saccharide interaction is a major player in the process of cell recognition. The study is focused on bacterial lectins responsible for virulence of the source bacteria, and developing a reliable in silico method capable of predicting the changes in binding behaviour, identifying promising directions leading to desired preference changes, reducing the time and cost related to performing the task in vitro. In silico mutagenesis (MODELLER/TRITON) was used to create mutant files and molecular docking (AUTODOCK/TRITON, DOCK/Chimera) to find the best binding orientations of lectins and saccharides. Molecular dynamics using AMBER software package was used to simulate physiological conditions more precisely, to further optimize the results and to evaluate the energetic properties. A comparison of experimental and computed values proved that the in silico method is able to correctly model the interaction and the preference changes in regard to mutations in the binding site. Lectin-saccharide interaction is a major player in the process of cell recognition. The study is focused on bacterial lectins responsible for virulence of the source bacteria, and developing a reliable in silico method capable of predicting the changes in binding behaviour, identifying promising directions leading to desired preference changes, reducing the time and cost related to performing the task in vitro. In silico mutagenesis (MODELLER/TRITON) was used to create mutant files and molecular docking (AUTODOCK/TRITON, DOCK/Chimera) to find the best binding orientations of lectins and saccharides. Molecular dynamics using AMBER software package was used to simulate physiological conditions more precisely, to further optimize the results and to evaluate the energetic properties. A comparison of experimental and computed values proved that the in silico method is able to correctly model the interaction and the preference changes in regard to mutations in the binding site. (en)
Title	DECIPHERING THE SUGAR PREFERENCE RULES - COMPUTER-ASSISTED PROTEIN ENGINEERING OF BACTERIAL LECTIN PA-IIL DECIPHERING THE SUGAR PREFERENCE RULES - COMPUTER-ASSISTED PROTEIN ENGINEERING OF BACTERIAL LECTIN PA-IIL (en)
skos:prefLabel	DECIPHERING THE SUGAR PREFERENCE RULES - COMPUTER-ASSISTED PROTEIN ENGINEERING OF BACTERIAL LECTIN PA-IIL DECIPHERING THE SUGAR PREFERENCE RULES - COMPUTER-ASSISTED PROTEIN ENGINEERING OF BACTERIAL LECTIN PA-IIL (en)
skos:notation	RIV/00216224:14310/08:00025002!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA303/06/0570), P(LC06030), Z(MSM0021622413)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Prokop, Martin Adam, Jan Koča, Jaroslav Wimmerová, Michaela Kříž, Zdeněk
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	362268
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00025002
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Lectins; computational chemistry; molecular docking; in silico mutagenesis (en)
http://linked.open.../riv/klicoveSlovo	molecular docking computational chemistry in silico mutagenesis Lectins
http://linked.open...ontrolniKodProRIV	[DFF4F7762601]
http://linked.open...v/mistoKonaniAkce	Athens
http://linked.open...i/riv/mistoVydani	OXFORD
http://linked.open...i/riv/nazevZdroje	33rd FEBS Congress and 11th IUBMB Conference
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomolecular centre Structure-function studies on lectins and adhesins from microbial patogens
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Adam, Jan Koča, Jaroslav Wimmerová, Michaela Prokop, Martin Kříž, Zdeněk
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open...ain/vavai/riv/wos	000256633300521
http://linked.open.../riv/zahajeniAkce	2008-06-28 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
issn	1742-464X
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	BLACKWELL PUBLISHING
http://localhost/t...ganizacniJednotka	14310

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software