About: v-Myb suppresses phorbol ester- and modifies retinoic acid-induced differentiation of human promonocytic U937 cells

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About: v-Myb suppresses phorbol ester- and modifies retinoic acid-induced differentiation of human promonocytic U937 cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	c-myb as well as v-myb oncogene code for transcription factors. They regulate transcription of specific target genes thus controling proliferation, differentiation and apoptosis of hematopoietic cells. Up-regulation of the c-myb expression or rearrangement/amplification of the myb locus are often involved in leukemogenesis. Enforced myb expression blocks differentiation of various leukemic cell lines. Human promonocytes U937 can be induced to differentiate to monocyte/macrophage-like cells using phorbol esters or to granulocytes using retinoic acid. In order to investigate transforming capability of v-myb, we expressed the v-myb oncogene of AMV in U937 cells. We found that v-Myb efficiently suppressed formation of macrophages upon treatment with phorbol ester. Some features of granulocytic differentiation of retinoic-acid-treated U937 cells were affected by the v-Myb protein as well. These results document that v-Myb is significantly involved in control of myeloid differentiation. c-myb as well as v-myb oncogene code for transcription factors. They regulate transcription of specific target genes thus controling proliferation, differentiation and apoptosis of hematopoietic cells. Up-regulation of the c-myb expression or rearrangement/amplification of the myb locus are often involved in leukemogenesis. Enforced myb expression blocks differentiation of various leukemic cell lines. Human promonocytes U937 can be induced to differentiate to monocyte/macrophage-like cells using phorbol esters or to granulocytes using retinoic acid. In order to investigate transforming capability of v-myb, we expressed the v-myb oncogene of AMV in U937 cells. We found that v-Myb efficiently suppressed formation of macrophages upon treatment with phorbol ester. Some features of granulocytic differentiation of retinoic-acid-treated U937 cells were affected by the v-Myb protein as well. These results document that v-Myb is significantly involved in control of myeloid differentiation. (en)
Title	v-Myb suppresses phorbol ester- and modifies retinoic acid-induced differentiation of human promonocytic U937 cells v-Myb suppresses phorbol ester- and modifies retinoic acid-induced differentiation of human promonocytic U937 cells (en)
skos:prefLabel	v-Myb suppresses phorbol ester- and modifies retinoic acid-induced differentiation of human promonocytic U937 cells v-Myb suppresses phorbol ester- and modifies retinoic acid-induced differentiation of human promonocytic U937 cells (en)
skos:notation	RIV/00216224:14310/08:00024695!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GD204/08/H054), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Šmarda, Jan Knopfová, Lucia
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	403560
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00024695
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	v-Myb; U937; differentiation; macrophage; phorbol ester; retinoic acid (en)
http://linked.open.../riv/klicoveSlovo	macrophage retinoic acid U937 phorbol ester differentiation v-Myb
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[441782A4399F]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanisms of the cell proliferation and differentiation
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Knopfová, Lucia Šmarda, Jan
http://linked.open...ain/vavai/riv/wos	000257128400003
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	0028-2685
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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