About: Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis

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About: Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Loss of programmed cell death pathways is one of the features of malignancy that complicate the response of cancer cells to therapy. Activation of alternative death pathways offers a promising approach to enhance efficiency of cancer chemotherapy. We analysed programmed cell death pathways of v-myb-transformed BM2 monobolasts induced by arsenic trioxide, cycloheximide and camptothecin. We show that cell death is not executed by caspases but rather by alternative cell death pathways: camptothecin induces the lysosome-dependent cell death, arsenic trioxide induces autophagy, and most of cycloheximide-treated BM2 cells die by necrosis. The fact that alternative cell death pathways can be switched in cells with defects in activation and/or function of caspases suggests that understanding and targeting of these pathways could improve therapy on cancer cells suffering from defective apoptosis. Loss of programmed cell death pathways is one of the features of malignancy that complicate the response of cancer cells to therapy. Activation of alternative death pathways offers a promising approach to enhance efficiency of cancer chemotherapy. We analysed programmed cell death pathways of v-myb-transformed BM2 monobolasts induced by arsenic trioxide, cycloheximide and camptothecin. We show that cell death is not executed by caspases but rather by alternative cell death pathways: camptothecin induces the lysosome-dependent cell death, arsenic trioxide induces autophagy, and most of cycloheximide-treated BM2 cells die by necrosis. The fact that alternative cell death pathways can be switched in cells with defects in activation and/or function of caspases suggests that understanding and targeting of these pathways could improve therapy on cancer cells suffering from defective apoptosis. (en)
Title	Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis (en)
skos:prefLabel	Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis Alternative pathways of programmed cell death are activated in cells with defective caspase-dependent apoptosis (en)
skos:notation	RIV/00216224:14310/08:00024573!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/07/0834), P(GA301/06/0036), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Horváth, Viktor Souček, Karel Šmarda, Jan Ondroušková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	355486
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00024573
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	apoptosis; autophagy; programmed cell death (en)
http://linked.open.../riv/klicoveSlovo	programmed cell death apoptosis autophagy
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CC648577540A]
http://linked.open...i/riv/nazevZdroje	Leukemia Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	A role of certain transcription factors in the osteoclastic differentiation pathway Role of transforming growth factor-beta in regulation of proliferation, differentiation and apoptosis in prostate and colon cancer
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Horváth, Viktor Souček, Karel Šmarda, Jan Ondroušková, Eva
http://linked.open...ain/vavai/riv/wos	000254724300012
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Molecular basis of cell and tissue regulations
issn	0145-2126
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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