About: The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo.     Goto   Sponge   NotDistinct   Permalink

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Description
  • Lrp5/6 are crucial coreceptors for Wnt/beta-catenin signaling, a pathway biochemically distinct from noncanonical Wnt signaling pathways. Here, we examined the possible participation of Lrp5/6 in noncanonical Wnt signaling using biochemical approach, and mouse and Xenopus in vivo models. We provide evidence that the extracellular domains of Lrp5/6 behave as physiologically relevant inhibitors of noncanonical Wnt signaling during Xenopus and mouse development in vivo.
  • Lrp5/6 are crucial coreceptors for Wnt/beta-catenin signaling, a pathway biochemically distinct from noncanonical Wnt signaling pathways. Here, we examined the possible participation of Lrp5/6 in noncanonical Wnt signaling using biochemical approach, and mouse and Xenopus in vivo models. We provide evidence that the extracellular domains of Lrp5/6 behave as physiologically relevant inhibitors of noncanonical Wnt signaling during Xenopus and mouse development in vivo. (en)
Title
  • The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo.
  • The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo. (en)
skos:prefLabel
  • The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo.
  • The Extracellular Domain of Lrp5/6 Inhibits Non-Canonical Wnt Signaling in vivo. (en)
skos:notation
  • RIV/00216224:14310/08:00024446!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 367478
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/08:00024446
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • non-canonical Wnt signalling; Lrp5/6; mouse; Xenopus (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [2BA557A07536]
http://linked.open...i/riv/nazevZdroje
  • : Molecular Biology of the Cell
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 20
http://linked.open...iv/tvurceVysledku
  • Bryja, Vítězslav
  • Andersson, Emma R.
  • Arenas, Ernest
  • Čajánek, Lukáš
  • Bryjová, Lenka
  • Schambony, Alexandra
  • Biris, Kristin K.
  • Buckingham, Margaret
  • Esner, Milan
  • Hall, Anita C.
  • Kraft, Bianca
  • Yamaguchi, Terry P.
http://linked.open...ain/vavai/riv/wos
  • 000263031900017
http://linked.open...n/vavai/riv/zamer
issn
  • 1059-1524
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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