About: Beta-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways

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About: Beta-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Recent advances in understanding beta-catenin-independent WNT (non-canonical) signaling suggest an increasing complexity, opening the question of how individual non-canonical pathways are induced and regulated. Here we examine whether intracellular signaling components such as beta-arrestin and casein kinase 1 and 2 (CK1 and 2) can contribute to determine signaling specificity in beta-catenin-independent WNT signaling to the small GTPase RAC-1. Our results suggest that the balance between beta-arrestin and CK1/2 determines whether WNT/RAC-1 or other non-canonical WNT pathways are activated. Recent advances in understanding beta-catenin-independent WNT (non-canonical) signaling suggest an increasing complexity, opening the question of how individual non-canonical pathways are induced and regulated. Here we examine whether intracellular signaling components such as beta-arrestin and casein kinase 1 and 2 (CK1 and 2) can contribute to determine signaling specificity in beta-catenin-independent WNT signaling to the small GTPase RAC-1. Our results suggest that the balance between beta-arrestin and CK1/2 determines whether WNT/RAC-1 or other non-canonical WNT pathways are activated. (en)
Title	Beta-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways Beta-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways (en)
skos:prefLabel	Beta-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways Beta-Arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways (en)
skos:notation	RIV/00216224:14310/08:00024435!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(KJB501630801), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Bryja, Vítězslav Čajánek, Lukáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	357824
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00024435
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	convergent extension movements; RAC-1; RHO-like GTPases; Xenopus laevis; WNT-5A (en)
http://linked.open.../riv/klicoveSlovo	WNT-5A Xenopus laevis RAC-1 RHO-like GTPases convergent extension movements
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[3B0744CB8AD7]
http://linked.open...i/riv/nazevZdroje	EMBO REPORTS
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Posttranslational modification of Dishevelled
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Schulte, Gunnar Arenas, Ernest Čajánek, Lukáš Schambony, Alexandra Dominguez, Isabel
http://linked.open...ain/vavai/riv/wos	000261325100018
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1469-221X
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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