About: Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The Bcl-2 protein is one of the key components of biochemical pathways controling programmed cell death. Function of this protein can be regulated by posttranslational modifications. Phosphorylation of Bcl-2 has been considered to be significantly associated with cell cycle arrest in the G2/M phase of the cell cycle, and with cell death caused by defects of microtubule dynamics. In this study, we show that heavy metal-induced stress and cell death correlate with induction of the Bcl-2 protein phosphorylation in several cell lines. Zinc-induced phosphorylation of Bcl-2 is mediated by the Jun N-terminal kinase pathway, and it is not linked to cell cycle arrest at G2/M. Cells of breast carcinoma cell line MDA-MB-231 expressing the wild-type Bcl-2 protein are more resistant to zinc-induced cell death than those expressing mutant variant of Bcl-2 that cannot be phosphorylated at amino acid residues Ser70, Ser87, Thr69. The Bcl-2 protein is one of the key components of biochemical pathways controling programmed cell death. Function of this protein can be regulated by posttranslational modifications. Phosphorylation of Bcl-2 has been considered to be significantly associated with cell cycle arrest in the G2/M phase of the cell cycle, and with cell death caused by defects of microtubule dynamics. In this study, we show that heavy metal-induced stress and cell death correlate with induction of the Bcl-2 protein phosphorylation in several cell lines. Zinc-induced phosphorylation of Bcl-2 is mediated by the Jun N-terminal kinase pathway, and it is not linked to cell cycle arrest at G2/M. Cells of breast carcinoma cell line MDA-MB-231 expressing the wild-type Bcl-2 protein are more resistant to zinc-induced cell death than those expressing mutant variant of Bcl-2 that cannot be phosphorylated at amino acid residues Ser70, Ser87, Thr69. (en)
Title	Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase (en)
skos:prefLabel	Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase (en)
skos:notation	RIV/00216224:14310/08:00024305!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/06/0036), P(IAA501630801), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Souček, Karel Beneš, Petr Šmarda, Jan Ondroušková, Eva Vaňková, Jana
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	369907
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00024305
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Bcl-2; heavy metals; Jun N-terminal kinase; phosphorylation; posttranslational modification (en)
http://linked.open.../riv/klicoveSlovo	posttranslational modification heavy metals Bcl-2 phosphorylation Jun N-terminal kinase
http://linked.open...ontrolniKodProRIV	[86B2ACE57B40]
http://linked.open...v/mistoKonaniAkce	Hradec Králové
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	XIX. Biologické dny. Biologický výzkum pro lidské zdraví
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanism of procathepsin D effect on breast cancer cells A role of certain transcription factors in the osteoclastic differentiation pathway
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Beneš, Petr Procházková, Jiřina Souček, Karel Šmarda, Jan Ondroušková, Eva Slováčková, Jana Pelková, Vendula
http://linked.open...vavai/riv/typAkce	CST - Celostátní
http://linked.open.../riv/zahajeniAkce	2008-01-01 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Československá biologická společnost a LF Univerzity Karlovy v Hradci Králové
https://schema.org/isbn	978-80-7399-545-4
http://localhost/t...ganizacniJednotka	14310

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