About: CATHEPSIN D : MANY FUNCTIONS OF ONE ASPARTIC PROTEASE

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	For years, it has been held that cathepsin D (CD) is involved in rather non-specific protein degradation in a strongly acidic milieu of lysosomes. Studies with CD knock-out mice revealed that CD is not necessary for embryonal development, but it is indispensable for postnatal tissue homeostasis. Mutation that abolishes CD enzymatic activity causes neuronal ceroid lipofuscinosis (NCL) characterized by severe neurodegeneration, developmental regression, visual loss and epilepsy in both animals and humans. In the last decade, however, an increasing number of studies demonstrated that enzymatic function of CD is not restricted solely to acidic milieu of lysosomes with important consequences in regulation of apoptosis. In addition to CD enzymatic activity, it has been shown that apoptosis is also regulated by catalytically inactive mutants of CD which suggests that CD interacts with other important molecules and influences cell signaling. For years, it has been held that cathepsin D (CD) is involved in rather non-specific protein degradation in a strongly acidic milieu of lysosomes. Studies with CD knock-out mice revealed that CD is not necessary for embryonal development, but it is indispensable for postnatal tissue homeostasis. Mutation that abolishes CD enzymatic activity causes neuronal ceroid lipofuscinosis (NCL) characterized by severe neurodegeneration, developmental regression, visual loss and epilepsy in both animals and humans. In the last decade, however, an increasing number of studies demonstrated that enzymatic function of CD is not restricted solely to acidic milieu of lysosomes with important consequences in regulation of apoptosis. In addition to CD enzymatic activity, it has been shown that apoptosis is also regulated by catalytically inactive mutants of CD which suggests that CD interacts with other important molecules and influences cell signaling. (en)
Title	CATHEPSIN D : MANY FUNCTIONS OF ONE ASPARTIC PROTEASE CATHEPSIN D : MANY FUNCTIONS OF ONE ASPARTIC PROTEASE (en)
skos:prefLabel	CATHEPSIN D : MANY FUNCTIONS OF ONE ASPARTIC PROTEASE CATHEPSIN D : MANY FUNCTIONS OF ONE ASPARTIC PROTEASE (en)
skos:notation	RIV/00216224:14310/08:00024162!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA501630801), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Beneš, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	358940
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00024162
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Alzheimer disease; Apoptosis; Atherosclerosis; Aspartic protease; Cancer; Cathepsin D; Knock-out mice; Procathepsin D (en)
http://linked.open.../riv/klicoveSlovo	Cancer Apoptosis Atherosclerosis Cathepsin D Alzheimer disease Aspartic protease Knock-out mice Procathepsin D
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3DCD254769EE]
http://linked.open...i/riv/nazevZdroje	Critical Reviews in Oncology/Hematology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanism of procathepsin D effect on breast cancer cells
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	68
http://linked.open...iv/tvurceVysledku	Beneš, Petr Fusek, Martin Větvička, Václav
http://linked.open...ain/vavai/riv/wos	000259895900002
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	1040-8428
number of pages	17 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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