About: Genetic variability of MHC class IIB genes associated with parasite diversity in European populations of chub (Leuciscus cephalus Linnaeus, 1758)

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About: Genetic variability of MHC class IIB genes associated with parasite diversity in European populations of chub (Leuciscus cephalus Linnaeus, 1758) Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The genes of the major histocompatibility complex (MHC) are the most polymorphic loci known for vertebrates. The host- pathogen coevolution and parasite-driven balancing selection have a extensive contribution to the high level of allelic diversity in MHC genes. The polymorphism of MHC molecules can be extremely huge; there are a large number of genetic variants (alleles) at each genetic locus. Individuals with higher number of different MHC molecules are able to recognize a broader spectrum of pathogen or parasite derived antigens, and then pathogens or parasites evolve to evade common MHC genotypes, giving rare MHC genotypes a selective advantage. A common European cyprinid, the chub, Leuciscus cephalus (L.), was chosen as a model organism for investigating the hypothesis of pathogen-driven selection under natural conditions, mediated either through heterozygous advantage (overdominant selection) or negative frequency-dependent selection (rare allele advantage hypothesis). The genes of the major histocompatibility complex (MHC) are the most polymorphic loci known for vertebrates. The host- pathogen coevolution and parasite-driven balancing selection have a extensive contribution to the high level of allelic diversity in MHC genes. The polymorphism of MHC molecules can be extremely huge; there are a large number of genetic variants (alleles) at each genetic locus. Individuals with higher number of different MHC molecules are able to recognize a broader spectrum of pathogen or parasite derived antigens, and then pathogens or parasites evolve to evade common MHC genotypes, giving rare MHC genotypes a selective advantage. A common European cyprinid, the chub, Leuciscus cephalus (L.), was chosen as a model organism for investigating the hypothesis of pathogen-driven selection under natural conditions, mediated either through heterozygous advantage (overdominant selection) or negative frequency-dependent selection (rare allele advantage hypothesis). (en)
Title	Genetic variability of MHC class IIB genes associated with parasite diversity in European populations of chub (Leuciscus cephalus Linnaeus, 1758) Genetic variability of MHC class IIB genes associated with parasite diversity in European populations of chub (Leuciscus cephalus Linnaeus, 1758) (en)
skos:prefLabel	Genetic variability of MHC class IIB genes associated with parasite diversity in European populations of chub (Leuciscus cephalus Linnaeus, 1758) Genetic variability of MHC class IIB genes associated with parasite diversity in European populations of chub (Leuciscus cephalus Linnaeus, 1758) (en)
skos:notation	RIV/00216224:14310/07:00041713!RIV11-MSM-14310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021622416)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vetešníková Šimková, Andrea Jarkovský, Jiří Vyskočilová, Martina Seifertová, Mária
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	423143
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00041713
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MHC class IIB genes Cyprinidae Selection Polymorphism (en)
http://linked.open.../riv/klicoveSlovo	MHC class IIB genes Cyprinidae Selection Polymorphism
http://linked.open...ontrolniKodProRIV	[CE95E40EACF3]
http://linked.open...in/vavai/riv/obor	EH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...iv/tvurceVysledku	Jarkovský, Jiří Vetešníková Šimková, Andrea Vyskočilová, Martina Seifertová, Mária
http://linked.open...n/vavai/riv/zamer	Diversity of Biotic Communities and Populations: Causal Analysis of variation in space and time
http://localhost/t...ganizacniJednotka	14310

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