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Description
  • A series of four bicyclic cores were prepared and evaluated and cyclin-dependent kinase-2 (CDK2) inhibitors. From the in vitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior for further elaboration in the identification of novel CDK2 inhibitors.
  • A series of four bicyclic cores were prepared and evaluated and cyclin-dependent kinase-2 (CDK2) inhibitors. From the in vitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior for further elaboration in the identification of novel CDK2 inhibitors. (en)
Title
  • Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors
  • Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors (en)
skos:prefLabel
  • Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors
  • Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors (en)
skos:notation
  • RIV/00216224:14310/07:00035882!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N
http://linked.open...iv/cisloPeriodika
  • 17
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 457821
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/07:00035882
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • kinases; template; CDK2 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [1728A6E96A41]
http://linked.open...i/riv/nazevZdroje
  • Bioorganic & Medicinal Chemistry Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 2007
http://linked.open...iv/tvurceVysledku
  • Alvarez, Carmen
  • Duca, Jose
  • Dwyer, Michael
  • Fischmann, Thierry
  • Guzi, Timothy
  • Keertikar, Kerry
  • Madison, Vincent
  • Parry, David
  • Paruch, Kamil
  • Seghezzi, Wolfgang
  • Wiswell, Derek
  • Shanahan, Frances
  • Doll, Ronald
  • Hruza, Alan
  • Lees, Emma
  • Sgambellone, Nicole
http://linked.open...ain/vavai/riv/wos
  • 000250906200035
issn
  • 0960-894X
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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