About: beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo     Goto   Sponge   NotDistinct   Permalink

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  • The phosphoprotein dishevelled (Dvl) is an integral part of Wnt signaling and has recently been shown to interact with the multifunctional scaffolding protein beta-arrestin. MEFs lacking beta-arrestins were able to phosphorylate Lrp6 in response to Wnt-3a, but decreased the activation of Dvl and blocked beta-catenin signaling. Furthermore, treatment of Xenopus laevis embryos with beta-arrestin morpholinos reduced the activation of endogenous beta-catenin, decreased the expression of the beta-catenin target gene, Xnr3, and blocked axis duplication induced by X-Wnt-8, and other molecules. Thus, our results identify beta-arrestin as a necessary component for Wnt/ beta-catenin signaling.
  • The phosphoprotein dishevelled (Dvl) is an integral part of Wnt signaling and has recently been shown to interact with the multifunctional scaffolding protein beta-arrestin. MEFs lacking beta-arrestins were able to phosphorylate Lrp6 in response to Wnt-3a, but decreased the activation of Dvl and blocked beta-catenin signaling. Furthermore, treatment of Xenopus laevis embryos with beta-arrestin morpholinos reduced the activation of endogenous beta-catenin, decreased the expression of the beta-catenin target gene, Xnr3, and blocked axis duplication induced by X-Wnt-8, and other molecules. Thus, our results identify beta-arrestin as a necessary component for Wnt/ beta-catenin signaling. (en)
Title
  • beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo
  • beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo (en)
skos:prefLabel
  • beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo
  • beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo (en)
skos:notation
  • RIV/00216224:14310/07:00025662!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50040507), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika
  • 16
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 411575
http://linked.open...ai/riv/idVysledku
  • RIV/00216224:14310/07:00025662
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • canonical Wnt signaling; dishevelled; Frizzled (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [DDE5BDA23289]
http://linked.open...i/riv/nazevZdroje
  • Proceedings of the National Academy of Sciences of the U.S.A.
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 104
http://linked.open...iv/tvurceVysledku
  • Bryja, Vítězslav
  • Gradl, D.
  • Schambony, A.
  • Schulte, G.
  • Arenas, E.
http://linked.open...ain/vavai/riv/wos
  • 000245869200037
http://linked.open...n/vavai/riv/zamer
issn
  • 1091-6490
number of pages
http://localhost/t...ganizacniJednotka
  • 14310
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