About: beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo

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About: beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The phosphoprotein dishevelled (Dvl) is an integral part of Wnt signaling and has recently been shown to interact with the multifunctional scaffolding protein beta-arrestin. MEFs lacking beta-arrestins were able to phosphorylate Lrp6 in response to Wnt-3a, but decreased the activation of Dvl and blocked beta-catenin signaling. Furthermore, treatment of Xenopus laevis embryos with beta-arrestin morpholinos reduced the activation of endogenous beta-catenin, decreased the expression of the beta-catenin target gene, Xnr3, and blocked axis duplication induced by X-Wnt-8, and other molecules. Thus, our results identify beta-arrestin as a necessary component for Wnt/ beta-catenin signaling. The phosphoprotein dishevelled (Dvl) is an integral part of Wnt signaling and has recently been shown to interact with the multifunctional scaffolding protein beta-arrestin. MEFs lacking beta-arrestins were able to phosphorylate Lrp6 in response to Wnt-3a, but decreased the activation of Dvl and blocked beta-catenin signaling. Furthermore, treatment of Xenopus laevis embryos with beta-arrestin morpholinos reduced the activation of endogenous beta-catenin, decreased the expression of the beta-catenin target gene, Xnr3, and blocked axis duplication induced by X-Wnt-8, and other molecules. Thus, our results identify beta-arrestin as a necessary component for Wnt/ beta-catenin signaling. (en)
Title	beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo (en)
skos:prefLabel	beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo (en)
skos:notation	RIV/00216224:14310/07:00025662!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50040507), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	16
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Bryja, Vítězslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	411575
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00025662
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	canonical Wnt signaling; dishevelled; Frizzled (en)
http://linked.open.../riv/klicoveSlovo	Frizzled canonical Wnt signaling dishevelled
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[DDE5BDA23289]
http://linked.open...i/riv/nazevZdroje	Proceedings of the National Academy of Sciences of the U.S.A.
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	104
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Gradl, D. Schambony, A. Schulte, G. Arenas, E.
http://linked.open...ain/vavai/riv/wos	000245869200037
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1091-6490
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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