About: X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives     Goto   Sponge   NotDistinct   Permalink

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  • Pseudomonas aeruginosa is an opportunistic bacterium showing increasing resistance to antibiotics and consequently represents elevated threatening problems in hospital environments, particularly for cystic fibrosis patients. The use of glycomimetics as an anti-adhesive strategy against microorganisms may complement the use of antibiotherapies. PA-IIL lectin (LecB) from P.aeruginosa constitutes an appealing target for antibacterial agents, as it has been proposed to play a key role in binding to airway epithelia and/or to be involved in biofilm formation. The lectin has an unusually high affinity for l-fucose and related oligosaccharides. In the work presented herein, the disaccharide aFuc1-4GlcNAc is used as a scaffold toward the synthesis of a series of glycomimetic derivatives.
  • Pseudomonas aeruginosa is an opportunistic bacterium showing increasing resistance to antibiotics and consequently represents elevated threatening problems in hospital environments, particularly for cystic fibrosis patients. The use of glycomimetics as an anti-adhesive strategy against microorganisms may complement the use of antibiotherapies. PA-IIL lectin (LecB) from P.aeruginosa constitutes an appealing target for antibacterial agents, as it has been proposed to play a key role in binding to airway epithelia and/or to be involved in biofilm formation. The lectin has an unusually high affinity for l-fucose and related oligosaccharides. In the work presented herein, the disaccharide aFuc1-4GlcNAc is used as a scaffold toward the synthesis of a series of glycomimetic derivatives. (en)
Title
  • X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives
  • X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives (en)
skos:prefLabel
  • X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives
  • X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives (en)
skos:notation
  • RIV/00216224:14310/07:00022341!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita
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  • P(LC06030)
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  • 9
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  • 461498
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  • RIV/00216224:14310/07:00022341
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  • Pseudomonas aeruginosa; lectin; inhibitors; structure; thermodynamics (en)
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  • DE - Spolková republika Německo
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  • [716D15CE01E9]
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  • ChemMedChem
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  • 2
http://linked.open...iv/tvurceVysledku
  • Imberty, Anne
  • Wimmerová, Michaela
  • Mitchell, Edward P.
  • Sabin, Charles
  • Marrote, Karine
  • Moumé-Pymbock, Myriam
  • Préville, Cathy
  • Roy, René
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  • 1860-7187
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  • 14310
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