About: Incidence of the main genetic markers in glioblastoma multiforme is independent of tumor topology

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About: Incidence of the main genetic markers in glioblastoma multiforme is independent of tumor topology Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Glioblastoma multiforme (GBM) is the most common as well as the most aggressive type of adult primary brain tumor of astrocytic origin. GBM is characterized by a high degree of intratumoral heterogeneity both in histomorphology and genetic changes. Nevertheless, trisomy/polysomy of chromosome 7, monosomy of chromosome 10, EGFR gene amplification and p53 deletion have been described as the typical genetic markers for tumor classification and prediction of possible response to therapy. Our work was based on detection of these four main genetic changes both in central and peripheral parts of the tumors to evaluate possible differences in the topological incidence of these genetic markers. Chromosomal abnormalities in tumor samples from a group of 21 patients surgically treated for GBM were characterized by means of the interphase-fluorescence in situ hybridization (I-FISH) technique using sets of centromere and locus-specific DNA probes. Glioblastoma multiforme (GBM) is the most common as well as the most aggressive type of adult primary brain tumor of astrocytic origin. GBM is characterized by a high degree of intratumoral heterogeneity both in histomorphology and genetic changes. Nevertheless, trisomy/polysomy of chromosome 7, monosomy of chromosome 10, EGFR gene amplification and p53 deletion have been described as the typical genetic markers for tumor classification and prediction of possible response to therapy. Our work was based on detection of these four main genetic changes both in central and peripheral parts of the tumors to evaluate possible differences in the topological incidence of these genetic markers. Chromosomal abnormalities in tumor samples from a group of 21 patients surgically treated for GBM were characterized by means of the interphase-fluorescence in situ hybridization (I-FISH) technique using sets of centromere and locus-specific DNA probes. (en)
Title	Incidence of the main genetic markers in glioblastoma multiforme is independent of tumor topology Incidence of the main genetic markers in glioblastoma multiforme is independent of tumor topology (en)
skos:prefLabel	Incidence of the main genetic markers in glioblastoma multiforme is independent of tumor topology Incidence of the main genetic markers in glioblastoma multiforme is independent of tumor topology (en)
skos:notation	RIV/00216224:14310/07:00022094!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(OC B19.001), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Veselská, Renata Vranová, Vladimíra Kuglík, Petr Cejpek, Pavel Pešáková, Martina Nečesalová, Eva Relichová, Jiřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	425897
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00022094
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	glioblastoma multiforme; molecular cytogenetics; FISH; array-CGH (en)
http://linked.open.../riv/klicoveSlovo	molecular cytogenetics FISH array-CGH glioblastoma multiforme
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[8B1D3F2A28F3]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20B19.001
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	54
http://linked.open...iv/tvurceVysledku	Jarošová, Marie Kuglík, Petr Veselská, Renata Vranová, Vladimíra Cejpek, Pavel Nečesalová, Eva Pešáková, Martina Relichová, Jiřina
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	0028-2685
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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