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rdf:type
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Description
| - Comparative genomic hybridization (CGH) is a molecular cytogenetic technique that allows genome-wide analysis of DNA sequence copy number differences. We have applied conventional CGH and recently developed high resolution CGH (HR-CGH) to tumour samples from 18 patients with glioblastoma multiforme (GBM) to compare the sensitivity of CGH and HR-CGH in the screening of chromosomal abnormalities. The abnormalities were studied in topologically different central and peripheral tumour parts. A total of 78 different changes were observed using CGH (0-16 per tumour, median 3.5) and 154 different changes using HR-CGH (0-21 per tumour, median 6). Using HR-CGH, losses were more frequent than gains. The representation of the most prominent changes revealed by both methods was similar and was comprised of the amplification of 7q12-13 and 12q12-q15, the gain of 7, 3q and 19 and the loss of 10, 9p, and 13q.
- Comparative genomic hybridization (CGH) is a molecular cytogenetic technique that allows genome-wide analysis of DNA sequence copy number differences. We have applied conventional CGH and recently developed high resolution CGH (HR-CGH) to tumour samples from 18 patients with glioblastoma multiforme (GBM) to compare the sensitivity of CGH and HR-CGH in the screening of chromosomal abnormalities. The abnormalities were studied in topologically different central and peripheral tumour parts. A total of 78 different changes were observed using CGH (0-16 per tumour, median 3.5) and 154 different changes using HR-CGH (0-21 per tumour, median 6). Using HR-CGH, losses were more frequent than gains. The representation of the most prominent changes revealed by both methods was similar and was comprised of the amplification of 7q12-13 and 12q12-q15, the gain of 7, 3q and 19 and the loss of 10, 9p, and 13q. (en)
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Title
| - Screening of genomic imbalances in glioblastoma multiforme using high-resolution comparative genomic hybridization
- Screening of genomic imbalances in glioblastoma multiforme using high-resolution comparative genomic hybridization (en)
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skos:prefLabel
| - Screening of genomic imbalances in glioblastoma multiforme using high-resolution comparative genomic hybridization
- Screening of genomic imbalances in glioblastoma multiforme using high-resolution comparative genomic hybridization (en)
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skos:notation
| - RIV/00216224:14310/07:00021808!RIV10-MSM-14310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(OC B19.001), Z(MSM0021622415)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/07:00021808
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - CGH; HR-CGH; glioblastoma multiforme; molecular cytogenetics (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kuglík, Petr
- Veselská, Renata
- Vranová, Vladimíra
- Budinská, Eva
- Cejpek, Pavel
- Nečesalová, Eva
- Pešáková, Martina
- Relichová, Jiřina
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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