About: Genome rearrangements in host-range mutants of the plyvalent staphylococcal bacteriophage 812

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About: Genome rearrangements in host-range mutants of the plyvalent staphylococcal bacteriophage 812 Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Mutations extended the host range of the polyvalent bacteriophage 812 of the family Myoviridae in up to 95 % of Staphylococcus aureus strains and 43 % of strains of different coagulase-positive and coagulase-negative Staphylococcus species. Mutational changes in the genome of several previously isolated host-range mutants of phage 812 were identified and described. Host-range mutant 812F1 harbors a deletion in endolysin gene that arose together with intron excision. Mutants 812i, 812b, 812p and 812F3 harbor deletion in the structural gene orf8 that results from a genome rearrangement that is associated with intron insertion. This rearrangement was also detected in the genome of the closely related phages, U16 and phi131. Another intron was discovered in the recA812 gene in mutants 812i, 812b, 812p and 812F3. An insertion was found in a non-coding region of the restriction fragment PstI-O of mutants 812b, 812F3 and 812g and phages U16 and phi131. Mutations extended the host range of the polyvalent bacteriophage 812 of the family Myoviridae in up to 95 % of Staphylococcus aureus strains and 43 % of strains of different coagulase-positive and coagulase-negative Staphylococcus species. Mutational changes in the genome of several previously isolated host-range mutants of phage 812 were identified and described. Host-range mutant 812F1 harbors a deletion in endolysin gene that arose together with intron excision. Mutants 812i, 812b, 812p and 812F3 harbor deletion in the structural gene orf8 that results from a genome rearrangement that is associated with intron insertion. This rearrangement was also detected in the genome of the closely related phages, U16 and phi131. Another intron was discovered in the recA812 gene in mutants 812i, 812b, 812p and 812F3. An insertion was found in a non-coding region of the restriction fragment PstI-O of mutants 812b, 812F3 and 812g and phages U16 and phi131. (en)
Title	Genome rearrangements in host-range mutants of the plyvalent staphylococcal bacteriophage 812 Genome rearrangements in host-range mutants of the plyvalent staphylococcal bacteriophage 812 (en)
skos:prefLabel	Genome rearrangements in host-range mutants of the plyvalent staphylococcal bacteriophage 812 Genome rearrangements in host-range mutants of the plyvalent staphylococcal bacteriophage 812 (en)
skos:notation	RIV/00216224:14310/07:00020477!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/03/0515), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kašpárek, Petr Doškař, Jiří Růžičková, Vladislava Pantůček, Roman Rájová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	423199
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00020477
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Staphylococcus bacteriophage; host-range; bacteriophage therapy; introns (en)
http://linked.open.../riv/klicoveSlovo	bacteriophage therapy Staphylococcus bacteriophage introns host-range
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[B9854E38E6D9]
http://linked.open...i/riv/nazevZdroje	Folia Microbiologica
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Integrated genome and proteome analysis of therapeutically important bacteriophages by combination of electrophoresis and mass spectrometry
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Doškař, Jiří Pantůček, Roman Růžičková, Vladislava Kašpárek, Petr Kahánková, Jana
http://linked.open...ain/vavai/riv/wos	000250290500003
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	0015-5632
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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