About: c-Jun induces apoptosis of serum-deprived BM2 monoblasts by activating cyclin A-associated CDK2 kinase

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About: c-Jun induces apoptosis of serum-deprived BM2 monoblasts by activating cyclin A-associated CDK2 kinase Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	c-Jun is one of the major components of the Activating Protein-1 (AP-1), the transcription factor that participates in regulation of proliferation, differentiation and apoptosis. In this study, we explored functional interactions of the c-Jun protein with several regulators of the G1/S transition in serum-deprived v-myb-transformed chicken monoblasts BM2. We show that the c-Jun protein induces expression of cyclin A, thus up-regulating activity of cyclin A-associated cyclin-dependent kinase 2 (CDK2), and causing massive programmed cell death of starved BM2cJUN cells. Specific inhibition of CDK2 suppresses frequency of apoptosis of BM2cJUN cells. We conclude that up-regulation of cyclin A-expression and CDK2 activity can represent important link between the c-Jun protein, cell cycle machinery and programmed cell death pathway in leukemic cells. c-Jun is one of the major components of the Activating Protein-1 (AP-1), the transcription factor that participates in regulation of proliferation, differentiation and apoptosis. In this study, we explored functional interactions of the c-Jun protein with several regulators of the G1/S transition in serum-deprived v-myb-transformed chicken monoblasts BM2. We show that the c-Jun protein induces expression of cyclin A, thus up-regulating activity of cyclin A-associated cyclin-dependent kinase 2 (CDK2), and causing massive programmed cell death of starved BM2cJUN cells. Specific inhibition of CDK2 suppresses frequency of apoptosis of BM2cJUN cells. We conclude that up-regulation of cyclin A-expression and CDK2 activity can represent important link between the c-Jun protein, cell cycle machinery and programmed cell death pathway in leukemic cells. (en)
Title	c-Jun induces apoptosis of serum-deprived BM2 monoblasts by activating cyclin A-associated CDK2 kinase c-Jun induces apoptosis of serum-deprived BM2 monoblasts by activating cyclin A-associated CDK2 kinase (en)
skos:prefLabel	c-Jun induces apoptosis of serum-deprived BM2 monoblasts by activating cyclin A-associated CDK2 kinase c-Jun induces apoptosis of serum-deprived BM2 monoblasts by activating cyclin A-associated CDK2 kinase (en)
skos:notation	RIV/00216224:14310/07:00020400!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/06/0036), Z(MSM0021622415)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hampl, Aleš Kozubík, Alois Vaňhara, Petr Horváth, Viktor Šmarda, Jan
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	413837
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00020400
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	c-Jun; cyclin A; CDK2; apoptosis; BM2 monoblast (en)
http://linked.open.../riv/klicoveSlovo	CDK2 cyclin A BM2 monoblast apoptosis c-Jun
http://linked.open...ontrolniKodProRIV	[3A561ED4E554]
http://linked.open...v/mistoKonaniAkce	Brno
http://linked.open...i/riv/mistoVydani	Brno
http://linked.open...i/riv/nazevZdroje	Analytical Cytometry IV
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	A role of certain transcription factors in the osteoclastic differentiation pathway
http://linked.open...UplatneniVysledku	2007
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Hampl, Aleš Horváth, Viktor Kozubík, Alois Šmarda, Jan Vaňhara, Petr
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2007-06-23 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Czech Society for Analytical Cytology
https://schema.org/isbn	978-80-239-9591-6
http://localhost/t...ganizacniJednotka	14310

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