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rdf:type
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Description
| - Using in vitro bioassay, we have found significant AhR-mediated activities of four out of twelve HS tested6. Applied bioassay is based on H4IIE-luc cells (rat hepatoma) stably transfected with a luciferase reporter gene under the control of dioxin-responsive element. In recent contribution, we summarize our new findings on interaction of AhR-active HS, being partial agonists of AhR, with full agonists of AhR, e.g. 2,3,7,8-TCDD. General toxicological principles suggest that partial agonists should antagonize action of full agonists; nevertheless our results have shown more likely contradictory effect. Supposed environmental consequences of our findings will be discussed.
- Using in vitro bioassay, we have found significant AhR-mediated activities of four out of twelve HS tested6. Applied bioassay is based on H4IIE-luc cells (rat hepatoma) stably transfected with a luciferase reporter gene under the control of dioxin-responsive element. In recent contribution, we summarize our new findings on interaction of AhR-active HS, being partial agonists of AhR, with full agonists of AhR, e.g. 2,3,7,8-TCDD. General toxicological principles suggest that partial agonists should antagonize action of full agonists; nevertheless our results have shown more likely contradictory effect. Supposed environmental consequences of our findings will be discussed. (en)
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Title
| - AhR-ACTIVE HUMIC SUBSTANCES - DANGER OR BENEFIT?
- AhR-ACTIVE HUMIC SUBSTANCES - DANGER OR BENEFIT? (en)
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skos:prefLabel
| - AhR-ACTIVE HUMIC SUBSTANCES - DANGER OR BENEFIT?
- AhR-ACTIVE HUMIC SUBSTANCES - DANGER OR BENEFIT? (en)
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skos:notation
| - RIV/00216224:14310/07:00020349!RIV11-GA0-14310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GP525/05/P160), Z(MSM0021622412)
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/07:00020349
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Humic substances; Ah receptor; Irradiation (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Giesy, John Paul
- Hilscherová, Klára
- Bittner, Michal
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http://linked.open...n/vavai/riv/zamer
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http://localhost/t...ganizacniJednotka
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