About: Review: Application of capillary electrophoresis in drug metabolism studies

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Capillary electrophoresis (CE) has been increasingly employed for the separation of pharmaceutical agents and drugs. This has arisen from the complementary mode of separation afforded by CE when compared to high performance liquid chromatography (HPLC). Qualities of CE such as high efficiency of separation, short analysis time, remarkably low injection volume and a variety of detection systems have facilitated acceptance of this technology. Since different drug metabolite enantiomers are formed in many metabolic pathways, the other indispensable advantage of CE over HPLC is the possibility of chiral separation without the need of special expensive columns. Recent advances in automated systems have made CE even more popular. The focus of this paper is to review recent studies and advances (mainly from 2000) of drug metabolism by using CE. The review is divided into two parts: (i) principles of CE separation of drugs and their metabolites and (ii) application of CE in drug metabolism studies. Capillary electrophoresis (CE) has been increasingly employed for the separation of pharmaceutical agents and drugs. This has arisen from the complementary mode of separation afforded by CE when compared to high performance liquid chromatography (HPLC). Qualities of CE such as high efficiency of separation, short analysis time, remarkably low injection volume and a variety of detection systems have facilitated acceptance of this technology. Since different drug metabolite enantiomers are formed in many metabolic pathways, the other indispensable advantage of CE over HPLC is the possibility of chiral separation without the need of special expensive columns. Recent advances in automated systems have made CE even more popular. The focus of this paper is to review recent studies and advances (mainly from 2000) of drug metabolism by using CE. The review is divided into two parts: (i) principles of CE separation of drugs and their metabolites and (ii) application of CE in drug metabolism studies. (en)
Title	Review: Application of capillary electrophoresis in drug metabolism studies Review: Application of capillary electrophoresis in drug metabolism studies (en)
skos:prefLabel	Review: Application of capillary electrophoresis in drug metabolism studies Review: Application of capillary electrophoresis in drug metabolism studies (en)
skos:notation	RIV/00216224:14310/07:00020296!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/06/0047), P(LC06023), Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Glatz, Zdeněk Konečný, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	447686
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00020296
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	capillary electrophoresis; drug metabolism (en)
http://linked.open.../riv/klicoveSlovo	drug metabolism capillary electrophoresis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B9D30E668CF9]
http://linked.open...i/riv/nazevZdroje	Current Analytical Chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Integrated bioanalytical technologies for microanalyses and diagnostics with laser induced fluorescence and mass spectrometry coupling. Capillary electrophoresis as a tool for the drug-metabolism studies
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	3
http://linked.open...iv/tvurceVysledku	Konečný, Jiří Glatz, Zdeněk Hoogmartens, Jos Van Schepdael, Ann Zhang, Jie
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
issn	1573-4110
number of pages	21 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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