About: Engineering of PA-IIL lectin from Pseudomonas aeruginosa - Unravelling the role of the specificity loop for sugar preference

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About: Engineering of PA-IIL lectin from Pseudomonas aeruginosa - Unravelling the role of the specificity loop for sugar preference Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Mutagenesis of amino acids forming the specificity binding loop in PA-IIL allowed identification of one amino acid that is crucial for definition of the lectin sugar preference. Altering specificity loop amino acids causes changes in saccharide-binding preferences of lectins derived from PA-IIL, via creation or blocking possible binding interactions. This finding opens a gate towards protein engineering and subsequent protein design to refine the desired binding properties and preferences, an approach that could have strong potential for drug design. Mutagenesis of amino acids forming the specificity binding loop in PA-IIL allowed identification of one amino acid that is crucial for definition of the lectin sugar preference. Altering specificity loop amino acids causes changes in saccharide-binding preferences of lectins derived from PA-IIL, via creation or blocking possible binding interactions. This finding opens a gate towards protein engineering and subsequent protein design to refine the desired binding properties and preferences, an approach that could have strong potential for drug design. (en)
Title	Engineering of PA-IIL lectin from Pseudomonas aeruginosa - Unravelling the role of the specificity loop for sugar preference Engineering of PA-IIL lectin from Pseudomonas aeruginosa - Unravelling the role of the specificity loop for sugar preference (en)
skos:prefLabel	Engineering of PA-IIL lectin from Pseudomonas aeruginosa - Unravelling the role of the specificity loop for sugar preference Engineering of PA-IIL lectin from Pseudomonas aeruginosa - Unravelling the role of the specificity loop for sugar preference (en)
skos:notation	RIV/00216224:14310/07:00020277!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA303/06/0570), P(GD204/03/H016), Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika	36
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pokorná, Martina Adam, Jan Wimmerová, Michaela Imberty, Anne
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	437325
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00020277
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lectin; pseudomonas aeruginosa; protein engineering; microcalorimetry; X-ray (en)
http://linked.open.../riv/klicoveSlovo	lectin pseudomonas aeruginosa X-ray microcalorimetry protein engineering
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[6CBC60D5AE23]
http://linked.open...i/riv/nazevZdroje	BMC Structural Biology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Structure-function studies on lectins and adhesins from microbial patogens Structural biophysics of macromolecules
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Adam, Jan Imberty, Anne Pokorná, Martina Wimmerová, Michaela Mitchell, Edward P. Sabin, Charles
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
issn	1472-6807
number of pages	13 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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