About: p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts

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About: p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The p53 protein can control cell cycle progression, programmed cell death and differentiation of many cell types. In this work, we expressed human p53 protein in v-Myb-transformed chicken monoblasts. We found that even this protein possessing only 53% amino acid homology to its avian counterpart can significantly alter morphology and physiology of these cells causing the G2-phase cell cycle arrest and early monocytic differentiation. Our results document that the species-specific differences of the p53 molecules, promoters/enhancers, and co-factors in avian and human cells do not interfere with differentiation- and cell cycle arrest promoting capabilites of the p53 tumor suppressor even in the presence of functional v-Myb oncoprotein. The p53-induced differentiation and cell cycle arrest of v-Myb-transformed monoblasts are not associated with apoptosis suggesting that the p53-driven pathways controling apoptosis and differentiation/proliferation are independent. The p53 protein can control cell cycle progression, programmed cell death and differentiation of many cell types. In this work, we expressed human p53 protein in v-Myb-transformed chicken monoblasts. We found that even this protein possessing only 53% amino acid homology to its avian counterpart can significantly alter morphology and physiology of these cells causing the G2-phase cell cycle arrest and early monocytic differentiation. Our results document that the species-specific differences of the p53 molecules, promoters/enhancers, and co-factors in avian and human cells do not interfere with differentiation- and cell cycle arrest promoting capabilites of the p53 tumor suppressor even in the presence of functional v-Myb oncoprotein. The p53-induced differentiation and cell cycle arrest of v-Myb-transformed monoblasts are not associated with apoptosis suggesting that the p53-driven pathways controling apoptosis and differentiation/proliferation are independent. (en)
Title	p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts (en)
skos:prefLabel	p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts (en)
skos:notation	RIV/00216224:14310/07:00020141!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/06/0036), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Lojek, Antonín Navrátilová, Jarmila Kozubík, Alois Horváth, Viktor Šmarda, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	446074
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00020141
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	p53; differentiation; cell cycle; apoptosis; monoblast (en)
http://linked.open.../riv/klicoveSlovo	p53 apoptosis cell cycle differentiation monoblast
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[18F1628286C8]
http://linked.open...i/riv/nazevZdroje	Differentiation
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	A role of certain transcription factors in the osteoclastic differentiation pathway
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	75
http://linked.open...iv/tvurceVysledku	Horváth, Viktor Kozubík, Alois Lojek, Antonín Šmarda, Jan Navrátilová, Jarmila Lipsick, Joseph
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Molecular basis of cell and tissue regulations
issn	0301-4681
number of pages	13 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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