Attributes | Values |
---|
rdf:type
| |
Description
| - c-Jun is one of the major components of the Activating Protein-1 (AP-1), the transcription factor that participates in regulation of proliferation, differentiation and apoptosis. In this study, we explored functional interactions of the c-Jun protein with several regulators of the G1/S transition in serum-deprived v-myb-transformed chicken monoblasts BM2. We show that the c-Jun protein induces expression of cyclin A, thus up-regulating activity of cyclin A-associated cyclin-dependent kinase 2 (CDK2), and causing massive programmed cell death of starved BM2cJUN cells. Specific inhibition of CDK2 suppresses frequency of apoptosis of BM2cJUN cells. We conclude that up-regulation of cyclin A-expression and CDK2 activity can represent important link between the c-Jun protein, cell cycle machinery and programmed cell death pathway in leukemic cells.
- c-Jun is one of the major components of the Activating Protein-1 (AP-1), the transcription factor that participates in regulation of proliferation, differentiation and apoptosis. In this study, we explored functional interactions of the c-Jun protein with several regulators of the G1/S transition in serum-deprived v-myb-transformed chicken monoblasts BM2. We show that the c-Jun protein induces expression of cyclin A, thus up-regulating activity of cyclin A-associated cyclin-dependent kinase 2 (CDK2), and causing massive programmed cell death of starved BM2cJUN cells. Specific inhibition of CDK2 suppresses frequency of apoptosis of BM2cJUN cells. We conclude that up-regulation of cyclin A-expression and CDK2 activity can represent important link between the c-Jun protein, cell cycle machinery and programmed cell death pathway in leukemic cells. (en)
|
Title
| - c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2
- c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2 (en)
|
skos:prefLabel
| - c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2
- c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2 (en)
|
skos:notation
| - RIV/00216224:14310/07:00020137!RIV10-MSM-14310___
|
http://linked.open...avai/riv/aktivita
| |
http://linked.open...avai/riv/aktivity
| - P(1M0538), P(GA301/06/0036), Z(AV0Z50040507), Z(AV0Z50040702), Z(AV0Z50390512), Z(AV0Z50390703), Z(MSM0021622415)
|
http://linked.open...iv/cisloPeriodika
| |
http://linked.open...vai/riv/dodaniDat
| |
http://linked.open...aciTvurceVysledku
| |
http://linked.open.../riv/druhVysledku
| |
http://linked.open...iv/duvernostUdaju
| |
http://linked.open...titaPredkladatele
| |
http://linked.open...dnocenehoVysledku
| |
http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/07:00020137
|
http://linked.open...riv/jazykVysledku
| |
http://linked.open.../riv/klicovaSlova
| - Jun; cyclin A; CDK2; apoptosis; v-myb-transformed monoblasts (en)
|
http://linked.open.../riv/klicoveSlovo
| |
http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
http://linked.open...ontrolniKodProRIV
| |
http://linked.open...i/riv/nazevZdroje
| - Biochemical and Biophysical Research Communications
|
http://linked.open...in/vavai/riv/obor
| |
http://linked.open...ichTvurcuVysledku
| |
http://linked.open...cetTvurcuVysledku
| |
http://linked.open...vavai/riv/projekt
| |
http://linked.open...UplatneniVysledku
| |
http://linked.open...v/svazekPeriodika
| |
http://linked.open...iv/tvurceVysledku
| - Bryja, Vítězslav
- Hampl, Aleš
- Horváth, Viktor
- Kozubík, Alois
- Šmarda, Jan
- Vaňhara, Petr
|
http://linked.open...ain/vavai/riv/wos
| |
http://linked.open...n/vavai/riv/zamer
| |
issn
| |
number of pages
| |
http://localhost/t...ganizacniJednotka
| |