About: A proteomic analysis of protein variations during differentiation of v-myb-transformed monoblasts

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: A proteomic analysis of protein variations during differentiation of v-myb-transformed monoblasts Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	v-myb-oncogene of avian myeloblastosis virus transforms myelomonocytic cells in vitro and induces acute monoblastic leukemia in vivo. The transforming effect of the v-myb can be suppressed using phorbol ester (TPA) or histone deacetylase inhibitor trichostatin A (TSA), the inducers of cell differentiation that are in clinical trials. In this study, we used proteomics-based approach to identify proteins with variable expression in differentiated BM2 cells. Proteome variations induced by TPA and TSA were compared to examine the mechanism of differentiation-promoting effects of these drugs. We found that expression of several proteins participating in cell cytoskeleton rearrangement, heat shock response, proteosynthesis and cell signaling was altered in TPA- or TSA-treated cells. We present here the first comparative proteome analysis of v-myb-transformed monoblasts BM2 focused on identification of proteins involved in their terminal differentiation. v-myb-oncogene of avian myeloblastosis virus transforms myelomonocytic cells in vitro and induces acute monoblastic leukemia in vivo. The transforming effect of the v-myb can be suppressed using phorbol ester (TPA) or histone deacetylase inhibitor trichostatin A (TSA), the inducers of cell differentiation that are in clinical trials. In this study, we used proteomics-based approach to identify proteins with variable expression in differentiated BM2 cells. Proteome variations induced by TPA and TSA were compared to examine the mechanism of differentiation-promoting effects of these drugs. We found that expression of several proteins participating in cell cytoskeleton rearrangement, heat shock response, proteosynthesis and cell signaling was altered in TPA- or TSA-treated cells. We present here the first comparative proteome analysis of v-myb-transformed monoblasts BM2 focused on identification of proteins involved in their terminal differentiation. (en)
Title	A proteomic analysis of protein variations during differentiation of v-myb-transformed monoblasts A proteomic analysis of protein variations during differentiation of v-myb-transformed monoblasts (en)
skos:prefLabel	A proteomic analysis of protein variations during differentiation of v-myb-transformed monoblasts A proteomic analysis of protein variations during differentiation of v-myb-transformed monoblasts (en)
skos:notation	RIV/00216224:14310/07:00020085!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/03/1055), P(GA301/06/0036), P(GP301/03/D022), Z(MSM0021622415)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Černá, Karolína Váňa, Petr Zdráhal, Zbyněk Beneš, Petr Šmarda, Jan Ondroušková, Eva Konečná, Hana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	408122
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00020085
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	v-myb; monoblast; macrophage; differentiation; proteome; two-dimensional gel electrophoresis; trichostatin A; TPA; mass spectrometry (en)
http://linked.open.../riv/klicoveSlovo	macrophage mass spectrometry TPA proteome trichostatin A two-dimensional gel electrophoresis differentiation v-myb monoblast
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[3175217B7FCA]
http://linked.open...i/riv/nazevZdroje	Leukemia Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of molecular mechanisms causing v-Myb suppression using proteomics-based approach A role of certain transcription factors in the osteoclastic differentiation pathway The role of vimentin in the monocyte/macrophage differentiation pathway
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Beneš, Petr Konečná, Hana Zdráhal, Zbyněk Černá, Karolína Šmarda, Jan Ondroušková, Eva Váňa, Petr
http://linked.open...n/vavai/riv/zamer	Molecular basis of cell and tissue regulations
issn	0145-2126
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 32 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software