About: A suggestion of electrochemical biosensor for study of Platinum(II)-DNA interactions

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About: A suggestion of electrochemical biosensor for study of Platinum(II)-DNA interactions Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	As a consequence of the employment of platinum based cytostatic drugs in tumor diseases treatment, it became necessary not only to detect them in biological samples but also to determine and study the Pt-DNA adducts, which is highly important during investigation of resistance on antitumor treatment. Thus, the main objective of this work was to study the interactions between DNA and cisplatin. Primarily, we studied changes in electrochemical behavior of cisplatin in the presence of different concentrations of sodium chloride using differential pulse voltammetry.We found out that the highest signal of cisplatin was measured in 0.75 M NaCl with detection limit of 100 pM. The current accepted opinion about platinum based cytostatics mechanism of action is that the drugs induce their cytotoxic properties through binding to the nuclear DNA. That is why we followed by investigation of DNA interactions with cisplatin. As a consequence of the employment of platinum based cytostatic drugs in tumor diseases treatment, it became necessary not only to detect them in biological samples but also to determine and study the Pt-DNA adducts, which is highly important during investigation of resistance on antitumor treatment. Thus, the main objective of this work was to study the interactions between DNA and cisplatin. Primarily, we studied changes in electrochemical behavior of cisplatin in the presence of different concentrations of sodium chloride using differential pulse voltammetry.We found out that the highest signal of cisplatin was measured in 0.75 M NaCl with detection limit of 100 pM. The current accepted opinion about platinum based cytostatics mechanism of action is that the drugs induce their cytotoxic properties through binding to the nuclear DNA. That is why we followed by investigation of DNA interactions with cisplatin. (en)
Title	A suggestion of electrochemical biosensor for study of Platinum(II)-DNA interactions A suggestion of electrochemical biosensor for study of Platinum(II)-DNA interactions (en)
skos:prefLabel	A suggestion of electrochemical biosensor for study of Platinum(II)-DNA interactions A suggestion of electrochemical biosensor for study of Platinum(II)-DNA interactions (en)
skos:notation	RIV/00216224:14310/07:00019367!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP525/04/P132), P(IAA100040602), Z(MSM0021622412), Z(MSM6215712402)
http://linked.open...iv/cisloPeriodika	2-3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Křížková, Soňa Stejskal, Karel Trnková, Libuše Adam, Vojtěch Zehnálek, Josef Kizek, René Zítka, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	408242
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/07:00019367
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	electrochemical biosensor; Platinum(II)-DNA interactions (en)
http://linked.open.../riv/klicoveSlovo	electrochemical biosensor Platinum(II)-DNA interactions
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[861B94E6EAA9]
http://linked.open...i/riv/nazevZdroje	Electroanalysis
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of protection mechanisms for stress-induced by heavy metals New approaches in electrochemical analysis of nucleic acids and oligonucleotides aimed at a ultrasensitive microdetection of DNA and DNA hybridization.
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Kizek, René Křížková, Soňa Stejskal, Karel Trnková, Libuše Zehnálek, Josef Zítka, Ondřej Petrlová, Jitka Sures, B. Beklová, M.
http://linked.open...n/vavai/riv/zamer	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) Veterinary aspects of food safety and quality
issn	1040-0397
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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