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Description
  • Fibroblast growth factor receptor 3 (FGFR3) is a membrane-anchored receptor tyrosine kinase that transmits intercellular signals mediated by a family of fibroblast growth factors (FGFs). In multiple myeloma (MM), 15% of patients markedly upregulate FGFR3 as a consequence of a t(4;14)(p16.3;q32) translocation. Ectopic expression of FGFR3 enhances MM cell proliferation and survival, demonstrating the oncogenic potential of FGFR3.
  • Fibroblast growth factor receptor 3 (FGFR3) is a membrane-anchored receptor tyrosine kinase that transmits intercellular signals mediated by a family of fibroblast growth factors (FGFs). In multiple myeloma (MM), 15% of patients markedly upregulate FGFR3 as a consequence of a t(4;14)(p16.3;q32) translocation. Ectopic expression of FGFR3 enhances MM cell proliferation and survival, demonstrating the oncogenic potential of FGFR3. (en)
Title
  • The fibroblast growth factors in multiple myeloma
  • The fibroblast growth factors in multiple myeloma (en)
skos:prefLabel
  • The fibroblast growth factors in multiple myeloma
  • The fibroblast growth factors in multiple myeloma (en)
skos:notation
  • RIV/00216224:14310/06:00064401!RIV13-MSM-14310___
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  • RIV/00216224:14310/06:00064401
http://linked.open...riv/jazykVysledku
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  • FACTOR RECEPTOR-3; EXPRESSION; MUTATIONS (en)
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  • GB - Spojené království Velké Británie a Severního Irska
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  • [6E64E496FACA]
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  • Leukemia
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  • 20
http://linked.open...iv/tvurceVysledku
  • Krejčí, Pavel
  • Mekikian, PB
  • Wilcox, WR
http://linked.open...ain/vavai/riv/wos
  • 000237806500038
issn
  • 0887-6924
number of pages
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  • 10.1038/sj.leu.2404202
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  • 14310
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