About: Shape-specific recognition in the structure of the Vts1p SAM domain with RNA

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About: Shape-specific recognition in the structure of the Vts1p SAM domain with RNA Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Although the abundant sterile alpha motif (SAM) domain was originally classified as a protein-protein interaction domain, it has recently been shown that certain SAM domains have the ability to bind RNA, defining a new type of post-transcriptional gene regulator. To further understand the function of SAM-RNA recognition, we determined the solution structures of the SAM domain of the Saccharomyces cerevisiae Vts1p (Vts1p-SAM) and the Smaug response element (SRE) stem-loop RNA as a complex and in isolation. The structures show that Vts1p-SAM recognizes predominantly the shape of the SRE rather than its sequence, with the exception of a G located at the tip of the pentaloop. Using microarray gene profiling, we identified several genes in S. cerevisiae that seem to be regulated by Vts1p and contain one or more copies of the SRE. Although the abundant sterile alpha motif (SAM) domain was originally classified as a protein-protein interaction domain, it has recently been shown that certain SAM domains have the ability to bind RNA, defining a new type of post-transcriptional gene regulator. To further understand the function of SAM-RNA recognition, we determined the solution structures of the SAM domain of the Saccharomyces cerevisiae Vts1p (Vts1p-SAM) and the Smaug response element (SRE) stem-loop RNA as a complex and in isolation. The structures show that Vts1p-SAM recognizes predominantly the shape of the SRE rather than its sequence, with the exception of a G located at the tip of the pentaloop. Using microarray gene profiling, we identified several genes in S. cerevisiae that seem to be regulated by Vts1p and contain one or more copies of the SRE. (en)
Title	Shape-specific recognition in the structure of the Vts1p SAM domain with RNA Shape-specific recognition in the structure of the Vts1p SAM domain with RNA (en)
skos:prefLabel	Shape-specific recognition in the structure of the Vts1p SAM domain with RNA Shape-specific recognition in the structure of the Vts1p SAM domain with RNA (en)
skos:notation	RIV/00216224:14310/06:00018474!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM0021622413)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Štefl, Richard
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	499137
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/06:00018474
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	SACCHAROMYCES-CEREVISIAE; REPRESSES TRANSLATION; DEADENYLASE COMPLEX; DROSOPHILA EMBRYO; DIPOLAR COUPLINGS; CRYSTAL-STRUCTURE; CCR4-NOT COMPLEX; GENE-EXPRESSION (en)
http://linked.open.../riv/klicoveSlovo	CRYSTAL-STRUCTURE SACCHAROMYCES-CEREVISIAE GENE-EXPRESSION CCR4-NOT COMPLEX DEADENYLASE COMPLEX DIPOLAR COUPLINGS DROSOPHILA EMBRYO REPRESSES TRANSLATION
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[CB0FD9691D65]
http://linked.open...i/riv/nazevZdroje	NATURE STRUCTURAL & MOLECULAR BIOLOGY
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Štefl, Richard Allain, Frederic Oberstrass, Florian Chanfreau, Guillaume Janis, Michael Lee, Albert
http://linked.open...n/vavai/riv/zamer	Proteiny v metabolismu a při interakci organismů s prostředím
issn	1545-9985
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14310

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