About: Relative quantification of tumor associated antigens MAGE-1 and MAGE-A3 in Multiple myeloma

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About: Relative quantification of tumor associated antigens MAGE-1 and MAGE-A3 in Multiple myeloma Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of this study was to evaluate the posibility of using these genes as molecular markers of the progression MGUS to MM and the early relapse of the MM. Due to rare extramedullary location of malignant plasma cells we tried to undercover if expression is detecable in PB simultaneously with expression in the BM. Total of 151 samples from BM were evaluated: 83 samples from advanced myeloma, 12 samples of patients with early stage of MM who did not required treatment (smoldering MM 4x, stage IA 8x), 41 samples of MGUS patiens and 15 samples of normal healthy donors served as control group. In 15 advanced myeloma patients we simultaneously assessed BM sample and PB sample. Total RNA was evaluated by RT-PCR and then by real-time PCR using FRET probes. For relative quantification we used G6PDH housekeeping gene as external standard. As positive control we used myeloma cell line U266. The aim of this study was to evaluate the posibility of using these genes as molecular markers of the progression MGUS to MM and the early relapse of the MM. Due to rare extramedullary location of malignant plasma cells we tried to undercover if expression is detecable in PB simultaneously with expression in the BM. Total of 151 samples from BM were evaluated: 83 samples from advanced myeloma, 12 samples of patients with early stage of MM who did not required treatment (smoldering MM 4x, stage IA 8x), 41 samples of MGUS patiens and 15 samples of normal healthy donors served as control group. In 15 advanced myeloma patients we simultaneously assessed BM sample and PB sample. Total RNA was evaluated by RT-PCR and then by real-time PCR using FRET probes. For relative quantification we used G6PDH housekeeping gene as external standard. As positive control we used myeloma cell line U266. (en)
Title	Relative quantification of tumor associated antigens MAGE-1 and MAGE-A3 in Multiple myeloma Relative quantification of tumor associated antigens MAGE-1 and MAGE-A3 in Multiple myeloma (en)
skos:prefLabel	Relative quantification of tumor associated antigens MAGE-1 and MAGE-A3 in Multiple myeloma Relative quantification of tumor associated antigens MAGE-1 and MAGE-A3 in Multiple myeloma (en)
skos:notation	RIV/00216224:14310/06:00017612!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(LC06027)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Penka, Miroslav Spěšná, Renata Nečasová, Jana Gaillyová, Renata Michálek, Jaroslav Kadlecová, Jitka
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	497107
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/06:00017612
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MAGE; multiple; myeloma; real-time; PCR (en)
http://linked.open.../riv/klicoveSlovo	myeloma PCR real-time multiple MAGE
http://linked.open...ontrolniKodProRIV	[1325165F1ED7]
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	University Research Centre - Czech Myeloma Group
http://linked.open...UplatneniVysledku	2006
http://linked.open...iv/tvurceVysledku	Gaillyová, Renata Michálek, Jaroslav Penka, Miroslav Kadlecová, Jitka Nečasová, Jana Spěšná, Renata
http://localhost/t...ganizacniJednotka	14310

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